Browsing by Subject "Oxidation-Reduction"
Now showing items 1-20 of 22
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A novel mutation of the ACADM gene (c.145C>G) associated with the common c.985A>G mutation on the other ACADM allele causes mild MCAD deficiency: a case report.
(Orphanet J Rare Dis, 2010-10-05)A female patient, with normal familial history, developed at the age of 30 months an episode of diarrhoea, vomiting and lethargy which resolved spontaneously. At the age of 3 years, the patient re-iterated vomiting, was ... -
Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: potentiometric, spectrophotometric and spectroelectrochemical study of protolytic and redox equilibria.
(Dalton Trans, 2010-12-28)The difference in electrostatics and reduction potentials between manganese ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP) and manganese meta-tetrakis(N-ethylpyridinium-3-yl)porphyrin (MnTE-3-PyP) is a challenging ... -
Curcumin Ameliorates Heat-Induced Injury through NADPH Oxidase-Dependent Redox Signaling and Mitochondrial Preservation in C2C12 Myoblasts and Mouse Skeletal Muscle.
(The Journal of nutrition, 2020-09)<h4>Background</h4>Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and the mitochondrial electron transport chain are the primary sources of reactive oxygen species (ROS). Previous studies have shown that severe ... -
Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.
(Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2013-01)Based on aqueous redox chemistry and simple in vivo models of oxidative stress, Escherichia coli and Saccharomyces cerevisiae, the cationic Mn(III) N-substituted pyridylporphyrins (MnPs) have been identified as the most ... -
Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.
(Inorganic chemistry, 2013-05-06)The different biological behavior of cationic Fe and Mn pyridylporphyrins in Escherichia coli and mouse studies prompted us to revisit and compare their chemistry. For that purpose, the series of ortho and meta isomers of ... -
Environmental conditions influence the plant functional diversity effect on potential denitrification.
(PLoS One, 2011-02-02)Global biodiversity loss has prompted research on the relationship between species diversity and ecosystem functioning. Few studies have examined how plant diversity impacts belowground processes; even fewer have examined ... -
Environmental Impacts of the Coal Ash Spill in Kingston, Tennessee: An 18-Month Survey
(2010)An 18 month investigation of the environmental impacts of the Tennessee Valley Authority (TVA) coal ash spill in Kingston, Tennessee combined with leaching experiments on the spilled TVA coal ash have revealed that leachable ... -
Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.
(The EMBO journal, 2017-08)O-GlcNAcylation is an essential, nutrient-sensitive post-translational modification, but its biochemical and phenotypic effects remain incompletely understood. To address this question, we investigated the global transcriptional ... -
Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes.
(Antioxid Redox Signal, 2016-03-01)AIMS: The differentiation of embryonic stem (ES) cells into energetically efficient cardiomyocytes contributes to functional cardiac repair and is envisioned to ameliorate progressive degenerative cardiac diseases. Advanced ... -
Homeostatic imbalance of purine catabolism in first-episode neuroleptic-naïve patients with schizophrenia.
(PLoS One, 2010-03-03)BACKGROUND: Purine catabolism may be an unappreciated, but important component of the homeostatic response of mitochondria to oxidant stress. Accumulating evidence suggests a pivotal role of oxidative stress in schizophrenia ... -
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
(Exp Gerontol, 2012-05)Here we explore association with human longevity of common genetic variation in three major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidants by investigating 1273 tagging ... -
Long-term transformation and fate of manufactured ag nanoparticles in a simulated large scale freshwater emergent wetland.
(Environ Sci Technol, 2012-07-03)Transformations and long-term fate of engineered nanomaterials must be measured in realistic complex natural systems to accurately assess the risks that they may pose. Here, we determine the long-term behavior of ... -
Mass spectrometry-based thermal shift assay for protein-ligand binding analysis.
(Anal Chem, 2010-07-01)Described here is a mass spectrometry-based screening assay for the detection of protein-ligand binding interactions in multicomponent protein mixtures. The assay utilizes an oxidation labeling protocol that involves using ... -
Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders.
(Antioxidants & redox signaling, 2014-05)<h4>Significance</h4>Metalloporphyrins, characterized by a redox-active transitional metal (Mn or Fe) coordinated to a cyclic porphyrin core ligand, mitigate oxidative/nitrosative stress in biological systems. Side-chain ... -
Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.
(Dalton transactions (Cambridge, England : 2003), 2011-04)Cationic Mn(III) N-alkylpyridylporphyrins (MnPs) are potent SOD mimics and peroxynitrite scavengers and diminish oxidative stress in a variety of animal models of central nervous system (CNS) injuries, cancer, radiation, ... -
Potential impacts of leakage from deep CO2 geosequestration on overlying freshwater aquifers.
(Environ Sci Technol, 2010-12-01)Carbon Capture and Storage may use deep saline aquifers for CO(2) sequestration, but small CO(2) leakage could pose a risk to overlying fresh groundwater. We performed laboratory incubations of CO(2) infiltration under oxidizing ... -
Redox rhythm reinforces the circadian clock to gate immune response.
(Nature, 2015-07-23)Recent studies have shown that in addition to the transcriptional circadian clock, many organisms, including Arabidopsis, have a circadian redox rhythm driven by the organism's metabolic activities. It has been hypothesized ... -
Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.
(Org Lett, 2010-09-17)A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, ... -
Sensor-mediated granular sludge reactor for nitrogen removal and reduced aeration demand using a dilute wastewater.
(Water environment research : a research publication of the Water Environment Federation, 2020-07)A sensor-mediated strategy was applied to a laboratory-scale granular sludge reactor (GSR) to demonstrate that energy-efficient inorganic nitrogen removal is possible with a dilute mainstream wastewater. The GSR was fed ... -
Supercritical water oxidation of a model fecal sludge without the use of a co-fuel.
(Chemosphere, 2015-12)A continuous supercritical water oxidation reactor was designed and constructed to investigate the conversion of a feces simulant without the use of a co-fuel. The maximum reactor temperature and waste conversion was determined ...
