Browsing by Subject "PI3K"
Now showing items 1-4 of 4
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A Paradoxical Role for PTEN in the Cellular Response to Hypoxia
(2010)Regulation of cell growth is controlled by a variety of factors, including a number of oncogenes and tumor suppressors. PTEN is an inositol phosphatase that regulates cell growth by hydrolyzing the phospholipid products ... -
The C. trachomatis effector protein TepP hijacks host cell signaling pathways to promote bacterial survival during infection.
(2017)Chlamydia trachomatis is a bacterial pathogen with a large socioeconomic impact: it is the leading cause of preventable blindness worldwide, and the most prevalent sexually transmitted infection in the United States. Despite ... -
The Effector TepP Mediates Recruitment and Activation of Phosphoinositide 3-Kinase on Early Chlamydia trachomatis Vacuoles.
(mSphere, 2017-07)Chlamydia trachomatis delivers multiple type 3 secreted effector proteins to host epithelial cells to manipulate cytoskeletal functions, membrane dynamics, and signaling pathways. TepP is the most abundant effector protein ... -
The Role of Phosphatidylinositol-3 Kinases and Phosphatidylinositol Phosphatases in T Cell Intracellular Homeostasis and Autophagy
(2013)The homeostasis of naïve T lymphocytes is maintained by several mechanisms involving basal TCR and cytokine signaling, and nutrient factors. One of the common net results of these input signals is the production and stabilization ...
