Browsing by Subject "PTEN Phosphohydrolase"

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Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.

Hu, X; Garcia, C; Fazli, L; Gleave, M; Vitek, MP; Jansen, M; Christensen, D; ... (8 authors) (Sci Rep, 2015-11-13)

The PP2A signaling axis regulates multiple oncogenic drivers of castration resistant prostate cancer (CRPC). We show that targeting the endogenous PP2A regulator, SET (I2PP2A), is a viable strategy to inhibit prostate cancers ...