Browsing by Subject "Pain Threshold"
Now showing items 1-8 of 8
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An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations.
(Anesth Analg, 2010-08)INTRODUCTION: We previously reported models that characterized the synergistic interaction between remifentanil and sevoflurane in blunting responses to verbal and painful stimuli. This preliminary study evaluated the ability ... -
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
(J Neurosci, 2002-12-01)Morphine induces antinociception by activating mu opioid receptors (muORs) in spinal and supraspinal regions of the CNS. (Beta)arrestin-2 (beta)arr2), a G-protein-coupled receptor-regulating protein, regulates the muOR in ... -
Exercise-induced pain intensity predicted by pre-exercise fear of pain and pain sensitivity.
(Clin J Pain, 2011-06)OBJECTIVES: Our primary goals were to determine whether preexisting fear of pain and pain sensitivity contributed to post-exercise pain intensity. METHODS: Delayed-onset muscle pain was induced in the trunk extensors of ... -
Investigating dynamic pain sensitivity in the context of the fear-avoidance model.
(Eur J Pain, 2015-01)BACKGROUND: Although nearly everyone at some point in their lives experiences back pain; the amount of interference with routine activity varies significantly. The fear-avoidance (FA) model of chronic pain explains ... -
Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain.
(Mol Pain, 2015-04-10)BACKGROUND: Mechanical and in particular tactile allodynia is a hallmark of chronic pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based neural tracing experiments and electrophysiology studies ... -
Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines.
(Journal of neuroinflammation, 2018-11-15)BACKGROUND:Preemptive administration of analgesic drugs reduces perceived pain and prolongs duration of antinociceptive action. Whereas several lines of evidence suggest that endomorphins, the endogenous mu-opioid agonists, ... -
Relationship of intersession variation in negative pain-related affect and responses to thermally-evoked pain.
(J Pain, 2010-02)UNLABELLED: The purpose of this study was to determine whether session-specific measures of negative pain-related affect would account for longitudinal variability in the ratings of the evoked thermal pain. Pain-free subjects ... -
Spinal manipulative therapy-specific changes in pain sensitivity in individuals with low back pain (NCT01168999).
(J Pain, 2014-02)UNLABELLED: Spinal manipulative therapy (SMT) is effective for some individuals experiencing low back pain; however, the mechanisms are not established regarding the role of placebo. SMT is associated with changes in pain ...
