Browsing by Subject "Parkinson Disease"

Coronal plane spinal malalignment and Parkinson's disease: prevalence and associations with disease severity.

Choi, Hong June; Smith, Justin S; Shaffrey, Christopher I; Lafage, Virginie C; Schwab, Frank J; Ames, Christopher P; Matsumoto, Morio; ... (9 authors) (The spine journal : official journal of the North American Spine Society, 2015-01)

<h4>Background context</h4>Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system. Patients with PD often present with abnormal posturing.<h4>Purpose</h4>To investigate coronal plane ...

Dissecting the Domains of Parkinson's Disease: Insights from Longitudinal Item Response Theory Modeling.

Luo, Sheng; Zou, Haotian; Stebbins, Glenn T; Schwarzschild, Michael A; Macklin, Eric A; Chan, James; Oakes, David; ... (10 authors) (Movement disorders : official journal of the Movement Disorder Society, 2022-09)

<h4>Background</h4>Longitudinal item response theory (IRT) models previously suggested that the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor examination has two salient domains, tremor ...

Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease.

Yadav, Amol P; Nicolelis, Miguel AL (Movement disorders : official journal of the Movement Disorder Society, 2017-06)

Spinal cord stimulation has been used for the treatment of chronic pain for decades. In 2009, our laboratory proposed, based on studies in rodents, that electrical stimulation of the dorsal columns of the spinal cord could ...

Guidance for switching from off-label antipsychotics to pimavanserin for Parkinson's disease psychosis: an expert consensus.

Black, Kevin J; Nasrallah, Henry; Isaacson, Stuart; Stacy, Mark; Pahwa, Rajesh; Adler, Charles H; Alva, Gustavo; ... (15 authors) (CNS spectrums, 2018-12)

Patients with Parkinson's disease psychosis (PDP) are often treated with an atypical antipsychotic, especially quetiapine or clozapine, but side effects, lack of sufficient efficacy, or both may motivate a switch to pimavanserin, ...

Impact of Movement Disorders on Management of Spinal Deformity in the Elderly.

Ha, Yoon; Oh, Jae Keun; Smith, Justin S; Ailon, Tamir; Fehlings, Michael G; Shaffrey, Christopher I; Ames, Christopher P (Neurosurgery, 2015-10)

Spinal deformities are frequent and disabling complications of movement disorders such as Parkinson disease and multiple system atrophy. The most distinct spinal deformities include camptocormia, antecollis, Pisa syndrome, ...

In-Hospital Complications and Resource Utilization Following Lumbar Spine Surgery in Patients with Parkinson Disease: Evaluation of the National Inpatient Sample Database.

Baker, Joseph F; McClelland, Shearwood; Line, Breton G; Smith, Justin S; Hart, Robert A; Ames, Christopher P; Shaffrey, Chris; ... (8 authors) (World neurosurgery, 2017-10)

<h4>Background</h4>Previous reports suggest that patients with Parkinson disease (PD) have elevated rates of complications following spine surgery; however, these reports are limited by small patient series. In this study, ...

Mindfulness based stress reduction in people with Parkinson's disease and their care partners.

Shah-Zamora, Deepal; Allen, Allison M; Rardin, Lacy; Ivancic, Margaret; Durham, Katie; Hickey, Patrick; Cooney, Jeffrey W; ... (9 authors) (Complementary therapies in clinical practice, 2021-05)

<h4>Background</h4>Parkinson's Disease (PD) leads to poor quality of life and caregiver burden. Mindfulness-based stress reduction (MBSR) may improve these symptoms. We assessed the impact of a 9-week MBSR course on people ...

Neuropsychiatric Issues in Parkinson's Disease.

Cooney, Jeffrey W; Stacy, Mark (Current neurology and neuroscience reports, 2016-05)

Cognitive and neuropsychiatric symptoms are common in Parkinson's Disease and may surpass motor symptoms as the major factors impacting patient quality of life. The symptoms may be broadly separated into those associated ...

Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial.

Investigators, NINDSNET-PDFS-ZONE (Lancet Neurol, 2015-08)

BACKGROUND: A systematic assessment of potential disease-modifying compounds for Parkinson's disease concluded that pioglitazone could hold promise for the treatment of patients with this disease. We assessed the effect ...

Prevalence and type of cervical deformities among adults with Parkinson's disease: a cross-sectional study.

Moon, Bong Ju; Smith, Justin S; Ames, Christopher P; Shaffrey, Christopher I; Lafage, Virginie; Schwab, Frank; Matsumoto, Morio; ... (9 authors) (Journal of neurosurgery. Spine, 2016-04)

<h4>Object</h4>To identify the characteristics of cervical deformities in Parkinson's disease (PD) and the role of severity of PD in the development of cervical spine deformities, the authors investigated the prevalence ...

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Cho, Kyoung-In; Searle, Kelly; Webb, Mason; Yi, Haiqing; Ferreira, Paulo A (Cell Mol Life Sci, 2012-10)

Many components and pathways transducing multifaceted and deleterious effects of stress stimuli remain ill-defined. The Ran-binding protein 2 (RanBP2) interactome modulates the expression of a range of clinical ...

Sagittal spinopelvic malalignment in Parkinson disease: prevalence and associations with disease severity.

Oh, Jae Keun; Smith, Justin S; Shaffrey, Christopher I; Lafage, Virginie; Schwab, Frank; Ames, Christopher P; Matsumoto, Morio; ... (9 authors) (Spine, 2014-06)

<h4>Study design</h4>Prospective study.<h4>Objective</h4>Our objectives were to evaluate the prevalence of sagittal spinopelvic malalignment in a consecutive series of patients with Parkinson disease (PD) and to identify ...

Speech motor program maintenance, but not switching, is enhanced by left-hemispheric deep brain stimulation in Parkinson's disease.

Jones, Harrison N; Kendall, Diane L; Okun, Michael S; Wu, Samuel S; Velozo, Craig; Fernandez, Hubert H; Spencer, Kristie A; ... (8 authors) (International journal of speech-language pathology, 2010-10)

Speech reaction time (SRT) was measured in a response priming protocol in 12 participants with Parkinson's disease (PD) and hypokinetic dysarthria "on" and "off" left-hemispheric deep brain stimulation (DBS). Speech preparation ...