Browsing by Subject "Parkinson's disease"
Now showing items 1-9 of 9
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Computational Analysis of Clinical Brain Sub-cortical Structures from Ultrahigh-Field MRI
(2015)Volumetric segmentation of brain sub-cortical structures within the basal ganglia and thalamus from Magnetic Resonance Image (MRI) is necessary for non-invasive diagnosis and neurosurgery planning. This is a challenging ... -
Effects of mitochondrial dynamics genes, fzo-1 and drp-1, on dopaminergic neurodegeneration induced by environmental exposure in Caenorhabditis elegans, as a model of Parkinson’s disease
(2015-05-30)Parkinson’s disease (PD) is caused by degeneration of the dopaminergic neurons; environmental toxicants are hypothesized to play a role in PD etiology. Environmental toxicants can cause mitochondrial dysfunction through ... -
Improved Efficacy and Efficiency of Non-Regular Temporal Patterns of Deep Brain Stimulation for Parkinson's Disease
(2015)Deep brain stimulation (DBS) is an effective therapy for motor symptoms in Parkinson's disease (PD). DBS efficacy depends on the stimulation parameters, and the current gold standard therapy is high-frequency stimulation ... -
Item Response Theory Analysis of the MDS-UPDRS Motor Examination: Tremor vs. Nontremor Items.
(Movement disorders : official journal of the Movement Disorder Society, 2020-05-29)BACKGROUND:In PD, tremor severity behaves differently from other core motor features. However, the most commonly used assessment of overall motor severity, total MDS-UPDRS Motor Examination (Part 3) score, does not account ... -
Non-Dopaminergic Motor Control: an Investigation of Serotonergic Circuitry in Parkinson’s Disease
(2018)The loss of nigrostriatal dopaminergic neurons is the fundamental hallmark of Parkinson’s disease (PD). In early PD stages, this is ameliorated by dopamine (DA) supplementation; however, as the disease progresses, the complete ... -
Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease.
(EBioMedicine, 2019-07)BACKGROUND:Extracellular vesicles (EVs) harbor thousands of proteins that hold promise for biomarker development. Usually difficult to purify, EVs in urine are relatively easily obtained and have demonstrated efficacy for ... -
Successful use of the Unified Dyskinesia Rating Scale regardless of PD- or dyskinesia-duration.
(Parkinsonism & related disorders, 2019-10)OBJECTIVE:We assessed differential item functioning (DIF) in the Unified Dyskinesia Rating Scale (UDysRS) to evaluate bias risk from the duration of Parkinson's Disease (PD) and duration of dyskinesia. BACKGROUND:Assessing ... -
The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease.
(Alzheimers Dement, 2017-02-24)It is hypothesized that retrotransposons have played a fundamental role in primate evolution and that enhanced neurologic retrotransposon activity in humans may underlie the origin of higher cognitive function. As a potential ... -
Uncovering the Neural Basis for Bradykinesia in Parkinson’s disease: Causality of Beta-frequency Oscillations
(2018)Substantial correlative evidence links the synchronized, oscillatory neural firing patterns that emerge in Parkinson’s disease (PD) in the frequency range of 13-30Hz (termed “beta band”) with the development of bradykinesia ...
