Browsing by Subject "Pathology"
Now showing items 1-20 of 28
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Acute Pathogenesis of Recombinant Vesicular Stomatitis Virus Vaccine Vectors is Linked to Interleukin-1
(2011)Recombinant vesicular stomatitis virus (rVSV) is a promising candidate viral vaccine vector for use in humans. VSV is highly immunogenic, pre-existing immunity to VSV is rare, and VSV is able to grow to high titers in cell ... -
Biochemical Characterization and Genetic Modeling of Glioma-Associated Mutations in Isocitrate Dehydrogenases.
(2014)Gliomas are the most common tumors of the central nervous system. Our lab recently identified mutations in <italic>IDH1</italic> and <italic>IDH2</italic> as occurring frequently in progressive gliomas. We applied a series ... -
Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Regulates Dendritic Cells and Myeloid Derived Suppressor Cells Development in the Lymphoma Microenvironment
(2016)Calcium (Ca2+) is a known important second messenger. Calcium/Calmodulin (CaM) dependent protein kinase kinase 2 (CaMKK2) is a crucial kinase in the calcium signaling cascade. Activated by Ca2+/CaM, CaMKK2 can phosphorylate ... -
Driving Brain Tumorigenesis: Generation and Biological Characterization of a Mutant IDH1 Mouse Model
(2014)Despite decades worth of research, glioblastoma remains one of the most lethal cancers. The identification of <italic>IDH1</italic> as a major cancer gene in glioblastoma provides an exceptional opportunity for improving ... -
Elucidating the Molecular Architecture of Cartilage by Proteomics
(2015)Articular cartilage is a highly specialized avascular tissue and consists of chondrocytes and two major components, a collagen-rich framework and highly abundant proteoglycans. The chondrocyte morphology and extracellular ... -
Enhancing Cisplatin Delivery and Anti-tumor Efficacy Using Hyperthermia
(2013)Mild hyperthermia (39°C-43°C) has numerous therapeutic benefits as an adjuvant therapy in the treatment of a variety of tumor types. Hyperthermia increases tumor blood flow and vascular permeability, promoting drug delivery ... -
Evaluation and Optimization of the Translational Potential of Array-Based Molecular Diagnostics
(2012)The translational potential of diagnostic and prognostic platforms developed using expression microarray technology is evident. However, the majority of array-based diagnostics have yet to make their way into the clinical ... -
Evaluation of LMP-420: A Novel, Nontoxic Drug with Anti-Inflammatory Properties and Therapeutic Potential for CLL
(2012)B-cell chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Although treatment of this disease has advanced considerably over the past decade, CLL remains incurable with current chemotherapeutics. ... -
Evaluation of Vaccine‐induced Maternal Antibody Transfer and Impact on Infant Immune Responses in the Rabbit Model
(2019)Maternal vaccination protects infants through transplacental transfer of vaccine-specific maternal IgG and milk transfer of IgG and IgA antibodies from mother to child. I performed experiments in the rabbit model, which ... -
Gastric Fluid Aspiration-Mediated Pulmonary Allograft Failure
(2013)Since its first success in 1983, lung transplantation has become the treatment of choice for selected patients with end stage lung disease. However, long-term graft survival is relatively low compared to other solid organs, ... -
Genetic Studies Identify Critical Biomarkers and Refine the Classification of Malignant Gliomas
(2014)Gliomagenesis is driven by a complex network of genetic alterations and while the glioma genome has been a focus of investigation for many years; critical gaps in our knowledge of this disease remain. The identification ... -
Genomic approaches to guide the molecular classification of glioma
(2019)Malignant gliomas account for more than 80% of all primary brain malignancies and 14,000 deaths in the U.S. annually. Despite aggressive treatment, malignant gliomas are largely fatal, as their invasive nature renders them ... -
Immunotoxin Monotherapy and Combinatorial Therapy With Immune Checkpoint Inhibitors for Malignant Brain Tumors
(2016)Glioblastoma is the most common and aggressive malignant brain tumor among all primary brain and central nervous system (CNS) tumors. The median survival time for glioblastoma patients given the current standard of care ... -
Investigation of Chondroprotective Mechanisms of Selenium
(2010)Selenium (Se) is an essential trace element and metalloid involved in several key metabolic activities: protection against oxidative damage, regulation of immune and thyroid function, and fertility. Several recent lines ... -
Lactate Metabolism in Cancer Cell Lines
(2013)Pathophysiologic lactate accumulation is characteristic of solid tumors and has been associated with metastases and poor overall survival in cancer patients. In recent years, there has been a resurgence of interest in tumor ... -
Mechanisms Regulating Pulmonary Sensitivity to Radiation
(2012)At the present time, here is no approved medical countermeasure (MCM) for mitigating or treating pneumonitis/fibrosis following acute radiation exposure. Since it is neither ethical nor feasible to evaluate potential MCMs ... -
Membrane GRP78: Pathologic and Therapeutic Roles in Ovarian Cancer
(2014)Ovarian cancer is the fifth leading cause of cancer-related death in the United States and the most lethal gynecologic malignancy. Patients with ovarian cancer are generally diagnosed at stage III or IV, when ascites fluid ... -
Molecular Characterization of Genetic and Epigenetic Alterations in Gliomas
(2012)Glioma development and progression are driven by complex genetic alterations, including point mutations and gain or loss of genomic copy number, as well as epigenetic aberrations, including DNA methylation and histone ... -
Mucosal Immunization for Cancer: Opportunities and Challenges
(2015)Cancer continues to be a large health and economic burden, despite advances in diagnostics and therapy. Cancer immunotherapy research and development of novel cancer vaccine strategies continues to grow, and new immunotherapy ... -
Nuclear Basic Fibroblast Growth Factor Regulation of Triple-Negative Breast Cancer Dormancy/Recurrence
(2014)Chemotherapy remains the only available treatment for triple-negative (TN) breast cancer. Although some TN breast cancers respond initially to neoadjuvant chemotherapy, the majority of patients die within three years of ...
