Browsing by Subject "Pharmaceutical sciences"
Now showing items 1-5 of 5
-
Development of Novel Antibody-Based Immunotherapies Targeting Human Chondroitin Sulfate Proteoglycan 4
(2018)Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target for cancer immunotherapy due to its high level of expression in a number of malignant tumors, and its essential role in tumor growth and progression. Clinical ... -
Exploiting Our Contemporary Understanding of the Molecular Pharmacology of the Estrogen Receptor to Develop Novel Therapeutics
(2020)The estrogen receptor (ER/ESR1) is expressed in the majority of breast and gynecological cancers. As such, drugs that inhibit ER signaling are the cornerstone of pharmacotherapy for these malignancies. Treatment strategies ... -
Sortase as a Tool in Biotechnology and Medicine
(2016)We have harnessed two reactions catalyzed by the enzyme sortase A and applied them to generate new methods for the purification and site-selective modification of recombinant protein therapeutics. We utilized native peptide ... -
Structure-Guided Development of Novel LpxC Inhibitors
(2013)The incessant increase of antibiotic resistance among Gram-negative pathogens is a serious threat to public health worldwide. A lack of new antimicrobial agents, particularly those against multidrug-resistant Gram-negative ... -
Targeting the Intrinsic Pathway of Coagulation with RNA Aptamers
(2013)Thrombosis is associated with the occlusion of a blood vessel and can be triggered by a number of types of injury, such as the rupture of an atherosclerotic plaque on the artery wall, changes in blood composition, or blood ...
