Now showing items 1-20 of 125

    • 29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome. 

      Lowe, Craig B; Haussler, David (PloS one, 2012-01)
      Recent research supports the view that changes in gene regulation, as opposed to changes in the genes themselves, play a significant role in morphological evolution. Gene regulation is largely dependent on transcription ...
    • A dimensionless number for understanding the evolutionary dynamics of antigenically variable RNA viruses. 

      Koelle, Katia; Ratmann, Oliver; Rasmussen, David A; Pasour, Virginia; Mattingly, Jonathan (Proc Biol Sci, 2011-12-22)
      Antigenically variable RNA viruses are significant contributors to the burden of infectious disease worldwide. One reason for their ubiquity is their ability to escape herd immunity through rapid antigenic evolution and ...
    • A high-resolution map of human evolutionary constraint using 29 mammals. 

      Lindblad-Toh, Kerstin; Garber, Manuel; Zuk, Or; Lin, Michael F; Parker, Brian J; Washietl, Stefan; Kheradpour, Pouya; ... (89 authors) (Nature, 2011-10-12)
      The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome ...
    • A molecular phylogeny of the fern family Pteridaceae: assessing overall relationships and the affinities of previously unsampled genera. 

      Schuettpelz, E; Schneider, H; Huiet, L; Windham, MD; Pryer, KM (Molecular phylogenetics and evolution, 2007-09)
      The monophyletic Pteridaceae accounts for roughly 10% of extant fern diversity and occupies an unusually broad range of ecological niches, including terrestrial, epiphytic, xeric-adapted rupestral, and even aquatic species. ...
    • A new fully automated approach for aligning and comparing shapes. 

      Boyer, Doug M; Puente, Jesus; Gladman, Justin T; Glynn, Chris; Mukherjee, Sayan; Yapuncich, Gabriel S; Daubechies, Ingrid (Anatomical record (Hoboken, N.J. : 2007), 2015-01)
      Three-dimensional geometric morphometric (3DGM) methods for placing landmarks on digitized bones have become increasingly sophisticated in the last 20 years, including greater degrees of automation. One aspect shared by ...
    • A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis. 

      Ribeiro, Ângela M; Zepeda-Mendoza, M Lisandra; Bertelsen, Mads F; Kristensen, Annemarie T; Jarvis, Erich D; Gilbert, M Thomas P; da Fonseca, Rute R (BMC Evol Biol, 2015-06-30)
      BACKGROUND: Hemostasis is a defense mechanism that enhances an organism's survival by minimizing blood loss upon vascular injury. In vertebrates, hemostasis has been evolving with the cardio-vascular and hemodynamic systems ...
    • Abrupt deceleration of molecular evolution linked to the origin of arborescence in ferns. 

      Korall, Petra; Schuettpelz, Eric; Pryer, Kathleen M (Evolution; international journal of organic evolution, 2010-09)
      Molecular rate heterogeneity, whereby rates of molecular evolution vary among groups of organisms, is a well-documented phenomenon. Nonetheless, its causes are poorly understood. For animals, generation time is frequently ...
    • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 

      Gustincich, Stefano; Batalov, Serge; Beisel, Kirk W; Bono, Hidemasa; Carninci, Piero; Fletcher, Colin F; Grimmond, Sean; ... (22 authors) (Genome Res, 2003-06)
      We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including ...
    • Anthropology. New World monkey origins. 

      Kay, Richard Frederick (Science, 2015-03-06)
    • apex: phylogenetics with multiple genes. 

      Jombart, Thibaut; Archer, Frederick; Schliep, Klaus; Kamvar, Zhian; Harris, Rebecca; Paradis, Emmanuel; Goudet, Jérome; ... (8 authors) (Mol Ecol Resour, 2017-01)
      Genetic sequences of multiple genes are becoming increasingly common for a wide range of organisms including viruses, bacteria and eukaryotes. While such data may sometimes be treated as a single locus, in practice, a number ...
    • Avian genomes. A flock of genomes. Introduction. 

      Zhang, Guojie; Jarvis, Erich D; Gilbert, M Thomas P (Science, 2014-12-12)
    • Biogeography in deep time - What do phylogenetics, geology, and paleoclimate tell us about early platyrrhine evolution? 

      Kay, Richard Frederick (Mol Phylogenet Evol, 2015-01)
      Molecular data have converged on a consensus about the genus-level phylogeny of extant platyrrhine monkeys, but for most extinct taxa and certainly for those older than the Pleistocene we must rely upon morphological evidence ...
    • Captivity humanizes the primate microbiome. 

      Clayton, Jonathan B; Vangay, Pajau; Huang, Hu; Ward, Tonya; Hillmann, Benjamin M; Al-Ghalith, Gabriel A; Travis, Dominic A; ... (17 authors) (Proc Natl Acad Sci U S A, 2018-03-01)
      The primate gastrointestinal tract is home to trillions of bacteria, whose composition is associated with numerous metabolic, autoimmune, and infectious human diseases. Although there is increasing evidence that modern and ...
    • Catarrhine hallucal metatarsals from the early Miocene site of Songhor, Kenya. 

      Patel, Biren A; Yapuncich, Gabriel S; Tran, Cassandra; Nengo, Isaiah O (Journal of human evolution, 2017-07)
      Songhor is an early Miocene fossil locality in Kenya known for its diverse primate assemblage that includes catarrhine species belonging to the genera Kalepithecus, Limnopithecus, Dendropithecus, Rangwapithecus, and Proconsul. ...
    • Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. 

      Falloon, Katie; Juvvadi, Praveen R; Richards, Amber D; Vargas-Muñiz, José M; Renshaw, Hilary; Steinbach, William J (PLoS One, 2015)
      Invasive aspergillosis, largely caused by Aspergillus fumigatus, is responsible for a growing number of deaths among immunosuppressed patients. Immunosuppressants such as FK506 (tacrolimus) that target calcineurin have shown ...
    • Chemical characterization of oligosaccharides in the milk of six species of New and Old World monkeys. 

      Goto, Kohta; Fukuda, Kenji; Senda, Akitsugu; Saito, Tadao; Kimura, Kazumasa; Glander, Kenneth E; Hinde, Katie; ... (12 authors) (Glycoconj J, 2010-10)
      Human and great ape milks contain a diverse array of milk oligosaccharides, but little is known about the milk oligosaccharides of other primates, and how they differ among taxa. Neutral and acidic oligosaccharides were ...
    • Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler. 

      Kepler, Thomas B; Sample, Christopher; Hudak, Kathryn; Roach, Jeffrey; Haines, Albert; Walsh, Allyson; Ramsburg, Elizabeth A (BMC Genomics, 2010-07-21)
      BACKGROUND: The rate of emergence of human pathogens is steadily increasing; most of these novel agents originate in wildlife. Bats, remarkably, are the natural reservoirs of many of the most pathogenic viruses in humans. ...
    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. 

      Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing; Gao, Feng; Alam, S Munir; Boyd, Scott D; Fire, Andrew Z; ... (45 authors) (Nature, 2013-04-25)
      Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details ...
    • Comparative genomics reveals insights into avian genome evolution and adaptation. 

      Alfaro-Núñez, A; Alström, P; An, N; Antunes, A; Avian Genome Consortium; Bertelsen, MF; Borges, R; ... (106 authors) (Science, 2014-12-12)
      Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. ...
    • Complete genome sequencing and analysis of six enterovirus 71 strains with different clinical phenotypes. 

      Wen, Hong-ling; Si, Lu-ying; Yuan, Xiao-jing; Hao, Shu-bin; Gao, Feng; Chu, Fu-lu; Sun, Cheng-xi; ... (8 authors) (Virol J, 2013-04-11)
      BACKGROUND: Hand, foot and mouth diseases (HFMD) caused by enterovirus 71(EV71) presents a broad spectrum of clinical manifestations ranging from mild febrile disease to fatal neurolocal disease. However, the mechanism of ...