Browsing by Subject "Plasmodium falciparum"
Now showing items 1-7 of 7
-
Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells.
(PloS one, 2016-01)Malaria detection through microscopic examination of stained blood smears is a diagnostic challenge that heavily relies on the expertise of trained microscopists. This paper presents an automated analysis method for detection ... -
Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum.
(Parasitology, 2009-01)Plasmodium falciparum parasites use multiple ligand-receptor interactions to invade human erythrocytes. Variant expression levels of members of the PfRh and PfEBA ligand families are associated with the use of different ... -
Hydroxyurea use and Plasmodium falciparum prevalence among children with sickle cell anemia in Homa Bay, Kenya; a cross sectional study
(2019)Hydroxyurea, a mainstay of sickle cell management in the developed world, offers a range of potential benefits to children with sickle cell disease. There is strong evidence that hydroxyurea induces production of fetal hemoglobin ... -
Investigating Transcription Factor Networks That Drive Biological Clocks and Oscillators
(2017)Biological systems are highly dynamic, yet our temporal resolution of suchdynamical processes is often limited or difficult to test in the laboratory. The 24-hourcircadian rhythm and the approximately 75-minute cell cycle ... -
Quantification of Plasmodium falciparum Cyclophilin 19B Transcripts Via qPCR in Normal and Sickle-Trait Hemoglobin Genotypes
(2021)The sickle-cell trait hemoglobin genotype (HbAS) is known to protect against severe malaria caused by Plasmodium falciparum. However, the biological mechanisms behind this protection are not well understood. Cyclophilin ... -
Single-Cell Analysis Reveals Distinct Gene Expression and Heterogeneity in Male and Female Plasmodium falciparum Gametocytes.
(mSphere, 2018-04-11)Sexual reproduction is an obligate step in the Plasmodium falciparum life cycle, with mature gametocytes being the only form of the parasite capable of human-to-mosquito transmission. Development of male and female gametocytes ... -
Using Single-Cell Analyses to Uncover Transcriptional Heterogeneity in Plasmodium falciparum
(2018)Malaria persists as a global health problem, with 212 million cases and 429,000 deaths worldwide in 2015 alone. It is caused by the apicomplexan parasite Plasmodium, which follows a complex life cycle that consists of multiple ...
