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Browsing by Subject "Porphyrins"

Now showing items 1-7 of 7

    • De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex. 

      Korendovych, Ivan V; Senes, Alessandro; Kim, Yong Ho; Lear, James D; Fry, H Christopher; Therien, Michael J; Blasie, J Kent; ... (9 authors) (J Am Chem Soc, 2010-11-10)
      The de novo design of membrane proteins remains difficult despite recent advances in understanding the factors that drive membrane protein folding and association. We have designed a membrane protein PRIME (PoRphyrins In ...

    • Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. 

      Tovmasyan, A; Sheng, H; Weitner, T; Arulpragasam, A; Lu, M; Warner, DS; Vujaskovic, Z; ... (9 authors) (Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2013-01)
      Based on aqueous redox chemistry and simple in vivo models of oxidative stress, Escherichia coli and Saccharomyces cerevisiae, the cationic Mn(III) N-substituted pyridylporphyrins (MnPs) have been identified as the most ...

    • H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways. 

      Batinic-Haberle, Ines; Tovmasyan, Artak; Huang, Zhiqing; Duan, Weina; Du, Li; Siamakpour-Reihani, Sharareh; Cao, Zhipeng; ... (10 authors) (Oxidative medicine and cellular longevity, 2021-01)
      Mn(III) ortho-N-alkyl- and N-alkoxyalkyl porphyrins (MnPs) were initially developed as superoxide dismutase (SOD) mimics. These compounds were later shown to react with numerous reactive species (such as ONOO-, H2O2, H2S, ...

    • Large Two-photon Absorption of Highly Conjugated Porphyrin Arrays and Their in vivo Applications 

      Park, Jong Kang (2015)
      Two-photon excited fluorescence microscopy (TPM) has become a standard biological imaging tool due to its simplicity and versatility. The fundamental contrast mechanism is derived from fluorescence of intrinsic or extrinsic ...

    • Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery. 

      Slastnikova, Tatiana A; Rosenkranz, Andrey A; Gulak, Pavel V; Schiffelers, Raymond M; Lupanova, Tatiana N; Khramtsov, Yuri V; Zalutsky, Michael R; ... (8 authors) (Int J Nanomedicine, 2012)
      BACKGROUND: Modular nanotransporters (MNT) are recombinant multifunctional polypeptides created to exploit a cascade of cellular processes, initiated with membrane receptor recognition to deliver selective short-range and ...

    • Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. 

      Batinić-Haberle, Ines; Rebouças, Júlio S; Spasojević, Ivan (Antioxid Redox Signal, 2010-09-15)
      Oxidative stress has become widely viewed as an underlying condition in a number of diseases, such as ischemia-reperfusion disorders, central nervous system disorders, cardiovascular conditions, cancer, and diabetes. Thus, ...

    • Water exchange rates of water-soluble manganese(III) porphyrins of therapeutical potential. 

      Budimir, Ana; Kalmár, József; Fábián, István; Lente, Gábor; Bányai, István; Batinić-Haberle, Ines; Birus, Mladen (Dalton Trans, 2010-05-14)
      The activation parameters and the rate constants of the water-exchange reactions of Mn(III)TE-2-PyP(5+) (meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin) as cationic, Mn(III)TnHex-2-PyP(5+) (meso-tetrakis(N-n-hexylpyridin...