Now showing items 1-7 of 7

    • Behaviourally driven gene expression reveals song nuclei in hummingbird brain. 

      Jarvis, ED; Ribeiro, S; da Silva, ML; Ventura, D; Vielliard, J; Mello, CV (Nature, 2000-08-10)
      Hummingbirds have developed a wealth of intriguing features, such as backwards flight, ultraviolet vision, extremely high metabolic rates, nocturnal hibernation, high brain-to-body size ratio and a remarkable species-specific ...
    • Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia. 

      Iwabuchi, Masahiro; Sheng, Huaxin; Thompson, J Will; Wang, Liangli; Dubois, Laura G; Gooden, David; Moseley, Marthur; ... (9 authors) (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014-03)
      Ubiquitylation is a posttranslational protein modification that modulates various cellular processes of key significance, including protein degradation and DNA damage repair. In animals subjected to transient cerebral ischemia, ...
    • Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. 

      Wang, Ya-Chao; Galeffi, Francesca; Wang, Wei; Li, Xuan; Lu, Liping; Sheng, Huaxin; Hoffmann, Ulrike; ... (9 authors) (Experimental neurology, 2020-04)
      <h4>Background and purpose</h4>Ischemic stroke significantly perturbs neuronal homeostasis leading to a cascade of pathologic events causing brain damage. In this study, we assessed acute stroke outcome after chemogenetic ...
    • Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice. 

      Zhang, Lin; Liu, Xiaozhi; Sheng, Huaxin; Liu, Shuai; Li, Ying; Zhao, Julia Q; Warner, David S; ... (9 authors) (Neuroscience, 2017-02)
      Small ubiquitin-like modifier (SUMO) conjugation (SUMOylation) plays key roles in neurologic function in health and disease. Neuronal SUMOylation is essential for emotionality and cognition, and this pathway is dramatically ...
    • Profiling of experience-regulated proteins in the songbird auditory forebrain using quantitative proteomics. 

      Pinaud, Raphael; Osorio, Cristina; Alzate, Oscar; Jarvis, Erich D (Eur J Neurosci, 2008-03)
      Auditory and perceptual processing of songs are required for a number of behaviors in songbirds such as vocal learning, territorial defense, mate selection and individual recognition. These neural processes are accompanied ...
    • Rudimentary substrates for vocal learning in a suboscine. 

      Liu, Wan-chun; Wada, Kazuhiro; Jarvis, Erich D; Nottebohm, Fernando (Nat Commun, 2013)
      Vocal learning has evolved in only a few groups of mammals and birds. The key neuroanatomical and behavioural links bridging vocal learners and non-learners are still unknown. Here we show that a non-vocal-learning suboscine, ...
    • Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice. 

      Yu, Shu; Galeffi, Francesca; Rodriguiz, Ramona M; Wang, Zhuoran; Shen, Yuntian; Lyu, Jingjun; Li, Ran; ... (15 authors) (FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020-11)
      Small ubiquitin-like modifier (SUMO1-3) conjugation (SUMOylation), a posttranslational modification, modulates almost all major cellular processes. Mounting evidence indicates that SUMOylation plays a crucial role in maintaining ...