Browsing by Subject "Prospective Studies"
Now showing items 1-20 of 292
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A blood-based biomarker panel to risk-stratify mild traumatic brain injury.
(PloS one, 2017-01)Mild traumatic brain injury (TBI) accounts for the vast majority of the nearly two million brain injuries suffered in the United States each year. Mild TBI is commonly classified as complicated (radiographic evidence of ... -
A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors.
(Journal of neurotrauma, 2012-09)To improve clinicians' ability to predict outcome after spinal cord injury (SCI) and to help classify patients within clinical trials, we have created a novel prediction model relating acute clinical and imaging information ... -
A Comparison of Minimally Invasive and Open Transforaminal Lumbar Interbody Fusion for Grade 1 Degenerative Lumbar Spondylolisthesis: An Analysis of the Prospective Quality Outcomes Database.
(Neurosurgery, 2020-09)<h4>Background</h4>It remains unclear if minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) is comparable to traditional, open TLIF because of the limitations of the prior small-sample-size, single-center ... -
A Comparison of Three Different Positioning Techniques on Surgical Corrections and Postoperative Alignment in Cervical Spinal Deformity (CD) Surgery.
(Spine, 2021-05)<h4>Study design</h4>Retrospective review of a prospective multicenter cervical deformity database.<h4>Objective</h4>To examine the differences in sagittal alignment correction between three positioning methods in cervical ... -
A Phase 3, Single-Arm, Prospective Study of Remestemcel-L, Ex Vivo Culture-Expanded Adult Human Mesenchymal Stromal Cells for the Treatment of Pediatric Patients Who Failed to Respond to Steroid Treatment for Acute Graft-versus-Host Disease.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2020-05)Steroid-refractory acute graft-versus-host disease (SR-aGVHD) following hematopoietic cell transplantation (HSCT) is associated with poor clinical outcomes. Currently, there are no safe and effective therapies approved for ... -
A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder.
(The Journal of pediatrics, 2020-07)<h4>Objective</h4>To evaluate whether umbilical cord blood (CB) infusion is safe and associated with improved social and communication abilities in children with autism spectrum disorder (ASD).<h4>Study design</h4>This ... -
A predictive model and nomogram for predicting return to work at 3 months after cervical spine surgery: an analysis from the Quality Outcomes Database.
(Neurosurgical focus, 2018-11)OBJECTIVEBack pain and neck pain are two of the most common causes of work loss due to disability, which poses an economic burden on society. Due to recent changes in healthcare policies, patient-centered outcomes including ... -
A prospective neurosurgical registry evaluating the clinical care of traumatic brain injury patients presenting to Mulago National Referral Hospital in Uganda.
(PloS one, 2017-01)<h4>Background</h4>Traumatic Brain Injury (TBI) is disproportionally concentrated in low- and middle-income countries (LMICs), with the odds of dying from TBI in Uganda more than 4 times higher than in high income countries ... -
A Randomized Phase II Crossover Study of Imatinib or Rituximab for Cutaneous Sclerosis after Hematopoietic Cell Transplantation.
(Clin Cancer Res, 2016-01-15)PURPOSE: Cutaneous sclerosis occurs in 20% of patients with chronic graft-versus-host disease (GVHD) and can compromise mobility and quality of life. EXPERIMENTAL DESIGN: We conducted a prospective, multicenter, randomized, ... -
Acute myocardial infarction under-diagnosis and mortality in a Tanzanian emergency department: A prospective observational study.
(American heart journal, 2020-08)BACKGROUND:Growing evidence suggests that under-diagnosis of acute myocardial infarction (AMI) may be common in sub-Saharan Africa. Prospective studies of routine AMI screening among patients presenting to emergency departments ... -
Adult Scoliosis Deformity Surgery: Comparison of Outcomes Between One Versus Two Attending Surgeons.
(Spine, 2017-07)<h4>Study design</h4>Retrospective review of prospectively collected data.<h4>Objective</h4>Assess outcomes of adult spinal deformity (ASD) surgery performed by one versus two attending surgeons.<h4>Summary of background ... -
Adult Spinal Deformity Patients Recall Fewer Than 50% of the Risks Discussed in the Informed Consent Process Preoperatively and the Recall Rate Worsens Significantly in the Postoperative Period.
(Spine, 2015-07)<h4>Study design</h4>Recall of the informed consent process in patients undergoing adult spinal deformity surgery and their family members was investigated prospectively.<h4>Objective</h4>To quantify the percentage recall ... -
AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection: a therapeutic dilemma in resource‐limited settings.
(Clin Infect Dis, 2010-11-01)AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection has not been adequately studied and poses unique therapeutic challenges in resource‐limited settings. Itraconazole poorly penetrates ... -
Alignment Risk Factors for Proximal Junctional Kyphosis and the Effect of Lower Thoracic Junctional Tethers for Adult Spinal Deformity.
(World neurosurgery, 2019-01)<h4>Objective</h4>The aims of this retrospective cohort study were to 1) identify new alignment risk factors for proximal junctional kyphosis (PJK) in adult spinal deformity (ASD) patients with lower thoracic upper instrumented ... -
Allogeneic human mesenchymal stem cell therapy (remestemcel-L, Prochymal) as a rescue agent for severe refractory acute graft-versus-host disease in pediatric patients.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2014-02)Severe steroid-refractory acute graft-versus-host disease (aGVHD) is related to significant mortality and morbidity after allogeneic stem cell transplantation. Early clinical trials of therapy with human mesenchymal stem ... -
An analysis from the Quality Outcomes Database, Part 1. Disability, quality of life, and pain outcomes following lumbar spine surgery: predicting likely individual patient outcomes for shared decision-making.
(Journal of neurosurgery. Spine, 2017-10)OBJECTIVE Quality and outcomes registry platforms lie at the center of many emerging evidence-driven reform models. Specifically, clinical registry data are progressively informing health care decision-making. In this analysis, ... -
An analysis from the Quality Outcomes Database, Part 2. Predictive model for return to work after elective surgery for lumbar degenerative disease.
(Journal of neurosurgery. Spine, 2017-10)OBJECTIVE Current costs associated with spine care are unsustainable. Productivity loss and time away from work for patients who were once gainfully employed contributes greatly to the financial burden experienced by individuals ... -
An analysis of emergency care delays experienced by traumatic brain injury patients presenting to a regional referral hospital in a low-income country.
(PloS one, 2020-01)<h4>Background</h4>Trauma is a leading cause of death and disability worldwide. In low- and middle-income countries (LMICs), trauma patients have a higher risk of experiencing delays to care due to limited hospital resources ... -
An Analysis of the Incidence and Outcomes of Major Versus Minor Neurological Decline After Complex Adult Spinal Deformity Surgery: A Subanalysis of Scoli-RISK-1 Study.
(Spine, 2018-07)<h4>Study design</h4>A subanalysis from a prospective, multicenter, international cohort study in 15 sites (Scoli-RISK-1).<h4>Objective</h4>To report detailed information regarding the severity of neurological decline related ... -
An evaluation of physician predictions of discharge on a general medicine service.
(J Hosp Med, 2015-12)The goal of this study was to evaluate general medicine physicians' ability to predict hospital discharge. We prospectively asked study subjects to predict whether each patient under their care would be discharged on the ...
