Browsing by Subject "Protein Design"
Now showing items 1-4 of 4
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Combined Computational, Experimental, and Assay-Development Studies of Protein:Protein and Protein:Small Molecule Complexes, with Applications to the Inhibition of Enzymes and Protein:Protein Interactions
(2019)Despite the best efforts of both academia and the pharma industry, most non-resectable cancers remain uncurable and lethal. The world health organization (WHO) believes cancer to be the second leading cause of death worldwide, ... -
Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design
(2018)Proteins are essential for myriad biological functions, including DNA replication, molecular transport, catalysis, and antigen recognition. Protein function is determined by three dimensional structure, which is largely ... -
Efficient Partition Function Estimation in Computational Protein Design: Probabalistic Guarantees and Characterization of a Novel Algorithm
(2015-05-07)By computational protein design we mean the use of computer algorithms to design new proteins or redesign existing ones. A significant challenge in this field involves computing the partition function of the ensemble of ... -
Novel Computational Protein Design Algorithms with Applications to Cystic Fibrosis and HIV
(2014)Proteins are essential components of cells and are crucial for catalyzing reactions, signaling, recognition, motility, recycling, and structural stability. This diversity of function suggests that nature is only scratching ...
