Browsing by Subject "Protein Interaction Mapping"
Now showing items 1-6 of 6
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A nucleosome-guided map of transcription factor binding sites in yeast.
(PLoS Comput Biol, 2007-11)Finding functional DNA binding sites of transcription factors (TFs) throughout the genome is a crucial step in understanding transcriptional regulation. Unfortunately, these binding sites are typically short and degenerate, ... -
Bayesian inference for genomic data integration reduces misclassification rate in predicting protein-protein interactions.
(PLoS Comput Biol, 2011-07)Protein-protein interactions (PPIs) are essential to most fundamental cellular processes. There has been increasing interest in reconstructing PPIs networks. However, several critical difficulties exist in obtaining reliable ... -
Domain-oriented edge-based alignment of protein interaction networks.
(Bioinformatics, 2009-06-15)MOTIVATION: Recent advances in high-throughput experimental techniques have yielded a large amount of data on protein-protein interactions (PPIs). Since these interactions can be organized into networks, and since separate ... -
DOMINE: a comprehensive collection of known and predicted domain-domain interactions.
(Nucleic acids research, 2011-01)DOMINE is a comprehensive collection of known and predicted domain-domain interactions (DDIs) compiled from 15 different sources. The updated DOMINE includes 2285 new domain-domain interactions (DDIs) inferred from experimentally ... -
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
(Nucleic acids research, 2018-09)Genomic sequencing of hepatocellular carcinoma (HCC) uncovers a paucity of actionable mutations, underscoring the necessity to exploit epigenetic vulnerabilities for therapeutics. In HCC, EZH2-mediated H3K27me3 represents ... -
Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.
(PLoS One, 2014)The molecular differences between ischemic (IF) and non-ischemic (NIF) heart failure are poorly defined. A better understanding of the molecular differences between these two heart failure etiologies may lead to the development ...
