Now showing items 1-6 of 6

    • Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites. 

      Collette, JR; Fernández-Golbano, IM; Geli, MI; Giblin, JP; Grötsch, H; Idrissi, FZ; Lemmon, Sandra K; ... (9 authors) (EMBO J, 2010-09-01)
      Myosins-I are conserved proteins that bear an N-terminal motor head followed by a Tail Homology 1 (TH1) lipid-binding domain. Some myosins-I have an additional C-terminal extension (C(ext)) that promotes Arp2/3 complex-dependent ...
    • FtsZ Protofilament Curvature Is the Opposite of Tubulin Rings. 

      Erickson, Harold Paul; Housman, Max; Milam, Sara L; Moore, Desmond A; Osawa, Masaki (Biochemistry, 2016-07)
      FtsZ protofilaments (pfs) form the bacterial cytokinetic Z ring. Previous work suggested that a conformational change from straight to curved pfs generated the constriction force. In the simplest model, the C-terminal membrane ...
    • Inside-out Z rings--constriction with and without GTP hydrolysis. 

      Erickson, Harold Paul; Osawa, Masaki (Molecular microbiology, 2011-07)
      The bacterial tubulin homologue FtsZ forms a ring-like structure called the Z ring that drives cytokinesis. We showed previously that FtsZ-YFP-mts, which has a short amphipathic helix (mts) on its C terminus that inserts ...
    • Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. 

      Cribbs, JT; Dagda, RK; Dickey, Audrey S; Green, SH; Merrill, RA; Strack, S; Usachev, YM (PLoS Biol, 2011-04)
      Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases of the dynamin family, mutation of which can cause neurological dysfunction. While fission-inducing protein phosphatases have been ...
    • The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation. 

      Chinnam, Nagababu; Erickson, Harold Paul; Ohashi, Tomoo; Schumacher, Maria; Shah, Riddhi Sanjay (The Journal of biological chemistry, 2013-11)
      Irisin was recently identified as a putative myokine that is induced by exercise. Studies suggest that it is produced by cleavage of the FNDC5 (fibronectin domain-containing protein 5) receptor; irisin corresponds to the ...
    • UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. 

      Chi, Q; Hagedorn, EJ; Linden, Lara M; Naegeli, KM; Savage, NS; Sherwood, David R; Wang, Z; ... (8 authors) (J Cell Biol, 2014-09-01)
      The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals toward its extracellular ligand netrin. How DCC polarizes toward netrin is poorly understood. By performing live-cell imaging ...