Now showing items 1-2 of 2

    • A SMAP in the face for cancer. 

      Shenolikar, Shirish (The Journal of clinical investigation, 2017-06)
      Observed deficits in protein phosphatase 2A (PP2A) function in a variety of human cancers have stimulated drug discovery efforts aimed at restoring PP2A function to inhibit tumor growth. Work published by Sangodkar et al. ...
    • Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. 

      Hu, X; Garcia, C; Fazli, L; Gleave, M; Vitek, MP; Jansen, M; Christensen, D; ... (8 authors) (Sci Rep, 2015-11-13)
      The PP2A signaling axis regulates multiple oncogenic drivers of castration resistant prostate cancer (CRPC). We show that targeting the endogenous PP2A regulator, SET (I2PP2A), is a viable strategy to inhibit prostate cancers ...