Now showing items 1-5 of 5

    • Curved FtsZ protofilaments generate bending forces on liposome membranes. 

      Osawa, Masaki; Anderson, David E; Erickson, Harold P (The EMBO journal, 2009-11)
      We have created FtsZ-YFP-mts where an amphipathic helix on the C-terminus tethers FtsZ to the membrane. When incorporated inside multi-lamellar tubular liposomes, FtsZ-YFP-mts can assemble Z rings that generate a constriction ...
    • FtsZ filament capping by MciZ, a developmental regulator of bacterial division. 

      Bisson-Filho, Alexandre W; Discola, Karen F; Castellen, Patrícia; Blasios, Valdir; Martins, Alexandre; Sforça, Maurício L; Garcia, Wanius; ... (11 authors) (Proceedings of the National Academy of Sciences of the United States of America, 2015-04-06)
      Cytoskeletal structures are dynamically remodeled with the aid of regulatory proteins. FtsZ (filamentation temperature-sensitive Z) is the bacterial homolog of tubulin that polymerizes into rings localized to cell-division ...
    • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. 

      McLellan, JS; Pancera, M; Carrico, C; Gorman, J; Julien, JP; Khayat, R; Louder, R; ... (47 authors) (Nature, 2011-11-23)
      Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are themselves protected by extraordinary sequence diversity ...
    • The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation. 

      Schumacher, Maria A; Chinnam, Nagababu; Ohashi, Tomoo; Shah, Riddhi Sanjay; Erickson, Harold P (The Journal of biological chemistry, 2013-11)
      Irisin was recently identified as a putative myokine that is induced by exercise. Studies suggest that it is produced by cleavage of the FNDC5 (fibronectin domain-containing protein 5) receptor; irisin corresponds to the ...
    • Visualization of arrestin recruitment by a G-protein-coupled receptor. 

      Shukla, Arun K; Westfield, Gerwin H; Xiao, Kunhong; Reis, Rosana I; Huang, Li-Yin; Tripathi-Shukla, Prachi; Qian, Jiang; ... (29 authors) (Nature, 2014-08-14)
      G-protein-coupled receptors (GPCRs) are critically regulated by β-arrestins, which not only desensitize G-protein signalling but also initiate a G-protein-independent wave of signalling. A recent surge of structural data ...