Browsing by Subject "Proteoglycans"
Now showing items 1-5 of 5
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Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254).
(Arthritis Res Ther, 2010)INTRODUCTION: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand ... -
Elucidating the Molecular Composition of Cartilage by Proteomics.
(J Proteome Res, 2016-02-05)Articular cartilage consists of chondrocytes and two major components, a collagen-rich framework and highly abundant proteoglycans. Most prior studies defining the zonal distribution of cartilage have extracted proteins ... -
Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4.
(Arthritis Rheum, 2010-06)OBJECTIVE: To assess the role of the glycoprotein PRG4 in joint lubrication and chondroprotection by measuring friction, stiffness, surface topography, and subsurface histology of the hip joints of Prg4(-/-) and wild-type ... -
Mechanobiology of the meniscus.
(J Biomech, 2015-06-01)The meniscus plays a critical biomechanical role in the knee, providing load support, joint stability, and congruity. Importantly, growing evidence indicates that the mechanobiologic response of meniscal cells plays a critical ... -
Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
(J Clin Invest, 2013-09)Cancers subvert the host immune system to facilitate disease progression. These evolved immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic strategies. Emerging data indicate that ...