Browsing by Subject "Proteoglycans"

Now showing items 1-5 of 5

    • Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). 

      Catterall, JB; Flannery, CR; Kraus, Virginia Byers; Stabler, Thomas (Arthritis Res Ther, 2010)
      INTRODUCTION: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand ...

    • Elucidating the Molecular Composition of Cartilage by Proteomics. 

      Hsueh, MF; Khabut, A; Kjellström, S; Kraus, Virginia Byers; Önnerfjord, P (J Proteome Res, 2016-02-05)
      Articular cartilage consists of chondrocytes and two major components, a collagen-rich framework and highly abundant proteoglycans. Most prior studies defining the zonal distribution of cartilage have extracted proteins ...

    • Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. 

      Coles, JM; Zhang, L; Blum, JJ; Warman, ML; Jay, GD; Guilak, Farshid; Zauscher, Stefan (Arthritis Rheum, 2010-06)
      OBJECTIVE: To assess the role of the glycoprotein PRG4 in joint lubrication and chondroprotection by measuring friction, stiffness, surface topography, and subsurface histology of the hip joints of Prg4(-/-) and wild-type ...

    • Mechanobiology of the meniscus. 

      Guilak, Farshid; McNulty, Amy (J Biomech, 2015-06-01)
      The meniscus plays a critical biomechanical role in the knee, providing load support, joint stability, and congruity. Importantly, growing evidence indicates that the mechanobiologic response of meniscal cells plays a critical ...

    • Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment. 

      Augustine, C; Beasley, G; Blobe, GC; Campbell, OM; Evans, Kathy; George, A; Gimpel, P; ... (20 authors) (J Clin Invest, 2013-09)
      Cancers subvert the host immune system to facilitate disease progression. These evolved immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic strategies. Emerging data indicate that ...