Now showing items 1-4 of 4

    • Phosphorylation at tyrosine 262 promotes GADD34 protein turnover. 

      Zhou, Wei; Jeyaraman, Krishna; Yusoff, Permeen; Shenolikar, Shirish (The Journal of biological chemistry, 2013-11)
      In mammalian cells, metabolic and environmental stress increases the phosphorylation of the eukaryotic translational initiation factor, eIF2α, and attenuates global protein synthesis. Subsequent transcriptional activation ...
    • Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity. 

      Battaglia, Rachel A; Beltran, Adriana S; Delic, Samed; Dumitru, Raluca; Robinson, Jasmine A; Kabiraj, Parijat; Herring, Laura E; ... (16 authors) (eLife, 2019-11-04)
      Alexander disease (AxD) is a fatal neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP), which supports the structural integrity of astrocytes. Over 70 GFAP missense mutations cause AxD, ...
    • The inoculum effect and band-pass bacterial response to periodic antibiotic treatment. 

      Tan, Cheemeng; Smith, Robert Phillip; Srimani, Jaydeep K; Riccione, Katherine A; Prasada, Sameer; Kuehn, Meta; You, Lingchong (Mol Syst Biol, 2012)
      The inoculum effect (IE) refers to the decreasing efficacy of an antibiotic with increasing bacterial density. It represents a unique strategy of antibiotic tolerance and it can complicate design of effective antibiotic ...
    • Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. 

      Harris, Katharine G; Coyne, Carolyn B (PloS one, 2015-01)
      Unc93b is an endoplasmic reticulum (ER)-resident transmembrane protein that serves to bind and traffic toll-like receptors (TLRs) from the ER to their appropriate subcellular locations for ligand sensing. Because of its ...