Browsing by Subject "Proteolysis"
Now showing items 1-7 of 7
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A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest.
(Cell reports, 2020-08)Cellular responses to stimuli can evolve over time, resulting in distinct early and late phases in response to a single signal. DNA damage induces a complex response that is largely orchestrated by the transcription factor ... -
BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation.
(Cell reports, 2020-09)Effective spatio-temporal control of transcription and replication during S-phase is paramount to maintaining genomic integrity and cell survival. Dysregulation of these systems can lead to conflicts between the transcription ... -
Phosphorylation at tyrosine 262 promotes GADD34 protein turnover.
(The Journal of biological chemistry, 2013-11)In mammalian cells, metabolic and environmental stress increases the phosphorylation of the eukaryotic translational initiation factor, eIF2α, and attenuates global protein synthesis. Subsequent transcriptional activation ... -
Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity.
(eLife, 2019-11-04)Alexander disease (AxD) is a fatal neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP), which supports the structural integrity of astrocytes. Over 70 GFAP missense mutations cause AxD, ... -
The inoculum effect and band-pass bacterial response to periodic antibiotic treatment.
(Mol Syst Biol, 2012)The inoculum effect (IE) refers to the decreasing efficacy of an antibiotic with increasing bacterial density. It represents a unique strategy of antibiotic tolerance and it can complicate design of effective antibiotic ... -
Translating antibody-binding peptides into peptoid ligands with improved affinity and stability.
(Journal of chromatography. A, 2019-09)A great number of protein-binding peptides are known and utilized as drugs, diagnostic reagents, and affinity ligands. Recently, however, peptide mimetics have been proposed as valuable alternative to peptides by virtue ... -
Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases.
(PloS one, 2015-01)Unc93b is an endoplasmic reticulum (ER)-resident transmembrane protein that serves to bind and traffic toll-like receptors (TLRs) from the ER to their appropriate subcellular locations for ligand sensing. Because of its ...
