Browsing by Subject "Provable Algorithms"
Now showing items 1-3 of 3
-
Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design
(2018)Proteins are essential for myriad biological functions, including DNA replication, molecular transport, catalysis, and antigen recognition. Protein function is determined by three dimensional structure, which is largely ... -
Novel Computational Protein Design Algorithms with Applications to Cystic Fibrosis and HIV
(2014)Proteins are essential components of cells and are crucial for catalyzing reactions, signaling, recognition, motility, recycling, and structural stability. This diversity of function suggests that nature is only scratching ... -
Novel Computational Protein Design Algorithms with Sparse Residue Interaction Graphs, Ensembles, and Mathematical Guarantees, and their Application to Antibody Design
(2018)Computational structure-based protein design seeks to harness the incredible biological power of proteins by designing proteins with new structures and even new function. In this dissertation, we present new algorithms to ...
