Now showing items 1-3 of 3

    • Activity of Galidesivir in a Hamster Model of SARS-CoV-2. 

      Taylor, Ray; Bowen, Richard; Demarest, James F; DeSpirito, Michael; Hartwig, Airn; Bielefeldt-Ohmann, Helle; Walling, Dennis M; ... (9 authors) (Viruses, 2021-12-21)
      Coronavirus disease 2019 (COVID-19) has claimed the lives of millions of people worldwide since it first emerged. The impact of the COVID-19 pandemic on public health and the global economy has highlighted the medical need ...
    • An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral. 

      Julander, Justin G; Demarest, James F; Taylor, Ray; Gowen, Brian B; Walling, Dennis M; Mathis, Amanda; Babu, YS (Antiviral research, 2021-09-20)
      Galidesivir (BCX4430) is an adenosine nucleoside analog that is broadly active in cell culture against several RNA viruses of various families. This activity has also been shown in animal models of viral disease associated ...
    • RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation. 

      Zhang, Xiaoling; Jin, Jane Y; Wu, Joseph; Qin, Xiaoxia; Streilein, Robert; Hall, Russell P; Zhang, Jennifer Y (J Invest Dermatol, 2015-04)
      Mice with epidermal deletion of JunB transcription factor displayed a psoriasis-like inflammation. The relevance of these findings to humans and the mechanisms mediating JunB function are not fully understood. Here we demonstrate ...