Browsing by Subject "Quantitative Trait Loci"
Now showing items 1-20 of 21
-
Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.
(Scientific reports, 2017-03-17)mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in ... -
Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.
(Oncotarget, 2016-12)Interleukin-17 plays a crucial role in inflammation-related carcinogenesis. We hypothesize that genetic variants in IL-17 are associated with gastric cancer (GCa) risk, and we genotyped five potentially functional single ... -
Beyond QTL cloning.
(PLoS Genet, 2010-11-11) -
Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans.
(PloS one, 2017-01)We previously showed that chromosome 8 of A/J mice was associated with susceptibility to S. aureus infection. However, the specific genes responsible for this susceptibility are unknown. Chromosome substitution strain 8 ... -
Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.
(PLoS One, 2010-10-27)The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from genetic changes that accumulate during population divergence. Indeed, much effort in recent years has been devoted to identifying genes ... -
Generalized admixture mapping for complex traits.
(G3 (Bethesda), 2013-07-08)Admixture mapping is a popular tool to identify regions of the genome associated with traits in a recently admixed population. Existing methods have been developed primarily for identification of a single locus influencing ... -
Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival.
(International journal of cancer, 2018-06)Cutaneous melanoma (CM) is considered as a steroid hormone-related malignancy. However, few studies have evaluated the roles of genetic variants encoding steroid hormone receptor genes and their related regulators (SHR-related ... -
Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk.
(International journal of cancer, 2018-04)The platelet-derived growth factor (PDGF) signaling pathway plays important roles in development and progression of human cancers. In our study, we aimed to identify genetic variants of the PDGF pathway genes associated ... -
Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study.
(Oncotarget, 2016-09)The Notch signaling pathway has been shown to have biological significance and therapeutic application in non-small cell lung cancer (NSCLC). We hypothesize that genetic variants of genes in the Notch signaling pathway are ... -
Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.
(PLoS One, 2013)Given the importance of cardiovascular disease (CVD) to public health and the demonstrated heritability of both disease status and its related risk factors, identifying the genetic variation underlying these susceptibilities ... -
Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors.
(Scientific reports, 2017-08-29)Anthracycline-based chemotherapy is associated with dose-dependent, irreversible damage to the heart. Childhood cancer survivors with hypertension after anthracycline exposure are at increased risk of cardiotoxicity, leading ... -
Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation.
(BMC Genomics, 2015-01-22)BACKGROUND: Expression quantitative trait loci (eQTL) play an important role in the regulation of gene expression. Gene expression levels and eQTLs are expected to vary from tissue to tissue, and therefore multi-tissue analyses ... -
Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
(PLoS Genet, 2015-11)Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) ... -
Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.
(The Journal of clinical investigation, 2016-08)Risk for ischemic stroke has a strong genetic basis, but heritable factors also contribute to the extent of damage after a stroke has occurred. We previously identified a locus on distal mouse chromosome 7 that contributes ... -
Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.
(PLoS genetics, 2013-01)During ischemic stroke, occlusion of the cerebrovasculature causes neuronal cell death (infarction), but naturally occurring genetic factors modulating infarction have been difficult to identify in human populations. In ... -
Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.
(Molecular carcinogenesis, 2018-02)The P38MAPK pathway participates in regulating cell cycle, inflammation, development, cell death, cell differentiation, and tumorigenesis. Genetic variants of some genes in the P38MAPK pathway are reportedly associated with ... -
Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains.
(Genetics, 2019-11)To identify genes involved in cerebral infarction, we have employed a forward genetic approach in inbred mouse strains, using quantitative trait loci (QTL) mapping for cerebral infarct volume after middle cerebral artery ... -
Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.
(PLoS Genet, 2014-11)Associating genetic variation with quantitative measures of gene regulation offers a way to bridge the gap between genotype and complex phenotypes. In order to identify quantitative trait loci (QTLs) that influence the binding ... -
Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.
(Cancer science, 2019-06)Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles ... -
Tissue-specific genetic control of splicing: implications for the study of complex traits.
(PLoS Biol, 2008-12-23)Numerous genome-wide screens for polymorphisms that influence gene expression have provided key insights into the genetic control of transcription. Despite this work, the relevance of specific polymorphisms to in vivo expression ...
