Browsing by Subject "Radiation"
Now showing items 1-15 of 15
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A Central Role for Hypoxia-inducible Transcription Factor Signaling in the Regulation of Skeletal Lineage Cells
(2022)Osteoporosis and low bone density affect an estimated 54 million adults of 50 years and over in the United States, resulting in $19 billion in costs for osteoporosis-related bone breaks. Current treatments include the use ... -
An Evaluation and Comparison of Beam Characteristics, Stray Radiation Room Surveys, Organ Dose, and Image Quality of Multiple Intra-Operative Imaging Devices for Orthopedic Lumbar Spinal Surgery
(2015)Purpose:The overall purpose of this study was a comparison of radiation exposure for patients and staff during intra-operative imaging for orthopedic lumbar spine surgery. In order to achieve this, we: (1) Characterized ... -
Assessing Dose Components to PET Technologists; Exploration of Novel Approach to PET Facility Shielding Design
(2012)Purpose: (1) To verify the accuracy and linearity of the ThermoScientific Radeye G Personal Rate Meter with respect to exposure rate across the full dynamic range of the instrument. (2) Use a combination of empirical data ... -
Dissecting Mechanisms of Tumor Response and Resistance to Radiation and Immunotherapy
(2020)Over half of all cancer patients receive radiation therapy, and it contributes to over 40% of cancer cures. Within the last decade, cancer immunotherapy has become a pillar of cancer therapy, along with surgery, chemotherapy, ... -
Effect of Radiation on Cardiovascular Function
(2020)There is a scarcity of knowledge regarding the cardiovascular effects of low dose ionizing radiation (IR) such as the one experienced during medical tests, radiation therapy or space travel. This is becoming more of a pressing ... -
Endogenous Retroviruses as a Key Modulator of Immune Response to Cancer Therapies
(2020)Endogenous retroviruses (ERVs) are ancient deactivated viral elements that have integrated into the human genome over the course of millennia of evolution. ERVs are normally kept transcriptionally repressed, but recent evidence ... -
Epigenetic Response to Low-Dose Ionizing Radiation
(2012)Low-dose ionizing radiation (LDIR) exposure (under 10.0 centigray (cGy)) from man-made sources, such as diagnostic imaging, predominates in the US population and comprises nearly 50% of an average individual's yearly radiation ... -
Implementation of Acuros XB Dose Calculation in to Clinical Radiation Therapy Workflows
(2022)Introduction: Stereotactic body radiation therapy (SBRT) is a common treatment techniquethat can be used to treat tumors for multiple cancer sites. Density heterogeneity in the target volume and beam path combined with small ... -
Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review.
(J Immunother Cancer, 2015)BACKGROUND: Ipilimumab improves survival in metastatic melanoma patients. This population frequently develops brain metastases, which have been associated with poor survival and are often treated with radiation. Therefore, ... -
Mechanisms by which p53 Regulates Radiation-induced Carcinogenesis and Myocardial Injury
(2012)Radiation therapy can cause acute toxicity and long-term side effects in normal tissues. Because part of the acute toxicity of radiation is due to p53-mediated apoptosis, blocking p53 during irradiation can protect some ... -
Monte Carlo Analysis and Physics Characterization of a Novel Nanoparticle Detector for Medical and Micro-dosimetry Applications
(2015)The outcomes for both (i) radiation therapy and (ii) preclinical small animal radio- biology studies are dependent on the delivery of a known quantity of radiation to a specific and intentional location. Adverse effects can ... -
Novel Methods of Optical Data Analysis to Assess Radiation Responses in the Tumor Microenvironment
(2013)The vascular contribution to tumor radiation response is controversial, but may have profound clinical implications. This is especially true of a new class of radiation therapies which employ spatial fractionation ... -
Novel Understandings of How Cancer Prevents and Responds to DNA Damage
(2020)Understanding the differences between normal and malignant tissue is required to find vulnerabilities in cancer that can be exploited. One of the hallmarks of cancer is its ability to sustain proliferative signaling, leading ... -
Using Genetically Engineered Mouse Models to Dissect the Critical Cellular Target of Radiation Therapy
(2018)Approximately half of all cancer patients will receive radiation as part of their treatment regimen in either a palliative or curative setting. Conventionally, radiation therapy has been administered to patients in small ... -
Validating the Use of Boron Nanoparticles to Quantify Tumor Oxygen Tension in Irradiated Breast Tumors
(2019)Although hypoxia in tumors has long been identified as a key contributor to poor patient outcome, clinical solutions to lessen its deleterious effects have not been forthcoming. One reason is that there have been few means ...
