Browsing by Subject "Radiation Therapy"
Now showing items 1-12 of 12
-
Accelerated Multi-Criterial Optimization in Radiation Therapy using Voxel-Wise Dose Prediction
(2020)In external beam radiation therapy (EBRT) for cancer patients, it is highly desirable to completely eradicate the cancerous cells for the purpose of improving the patient’s quality of life and increasing the patient’s likelihood ... -
An in vivo Investigation of Spatially Fractionated Radiation in Combination with Anti-PD-1 Blockade Immunotherapy
(2023)Purpose: GRID therapy (Spatially Fractionated RT) has the potential to amplify systemic anti-tumor immune effect. The optimal GRID design, radiation dosage and combination with immunotherapies are not well understood. In ... -
An Investigation of GRID and Spatially Fractionated Radiation Therapy: Dosimetry and Preclinical Trial
(2021)Purpose: To develop and implement novel methods of extreme spatially fractionated radiation therapy (including GRID therapy) and subsequent evaluation in pre-clinical mice trials investigating the potential of novel radiation ... -
Assessment of Variability in Liver Tumor Contrast in MRI for Radiation Therapy
(2017)Purpose: To investigate the inter-patient and inter-sequence variation in liver tumor contrast in MRI and the feasibility of improving the liver tumor contrast by using an in-house developed multi-source adaptive fusion ... -
Developing a Quality Index for Dose-Volume Histograms Based on Physician Preference
(2015)The purpose of this study was to create a DVH quality index that can be used as a comparison tool between two separate plans and as a clinical workflow tool to improve plan quality resulting in better patient outcome. To ... -
Investigation of Deformable Image Registration Based Lung Ventilation Mapping for Radiation Therapy Using a Hybrid Hyperpolarized Gas MRI Technique
(2020)Radiation-induced pulmonary toxicity poses a serious challenge and limiting factor in delivering a sufficient amount of dose to eradicate thoracic tumors without compromising lung function. Functional avoidance radiation ... -
Knowledge Discovery in Databases of Radiation Therapy Treatment Planning
(2017)Radiation has been utilized in medical domain for multiple purposes. Treating cancer using radiation has increasing popularity during the last century. Radiation beam is directed to the tumor cells while the surrounding ... -
Modeling and Maximizing Cherenkov Emissions from Medical Linear Accelerators: A Monte Carlo Study
(2017)Purpose: Cherenkov light is a natural byproduct of MV radiotherapy; recent results demonstrate that it can activate the drug psoralen sufficiently to induce cytotoxicity and increase MHC1 signal in vitro. Here, we investigate ... -
Optimization of RapidArc for Head-and-Neck Radiotherapy
(2011)<bold>Purpose:</bold> The goal of this planning study is to determine which sectors of the gantry rotation are most and least important in the treatment of head-and-neck carcinomas with Intensity Modulated Arc Therapy, and ... -
Techniques to Improve Gynecological High-Dose-Rate Brachytherapy Treatments
(2019)The thesis has two parts. The first project relates to real time dosimetry in Gynecological (GYN) High Dose Rate (HDR) Brachytherapy Treatments and the second part investigates a new workflow for Image Guided Brachytherapy ... -
The Feasibly of Functionally Guided Intensity Modulated Radiation Therapy Treatment Planning Using Perfluoropropane-Enhanced MRI for Lung Cancer
(2016)Radiotherapy is commonly used to treat lung cancer. However, radiation induced damage to lung tissue is a major limiting factor to its use. To minimize normal tissue lung toxicity from conformal radiotherapy treatment ... -
The Need for Adaptive Intensity Modulated Radiotherapy Replanning in Head-and-Neck Patients with Anatomical Changes During Treatment
(2013)AbstractPurpose: The aim of this study is to quantify the effectiveness of adaptive radiation therapy (ART) when anatomical changes to the tumor and/or the organs are observed for head and neck patients during the course ...
