Browsing by Subject "Randomized Controlled Trials as Topic"
Now showing items 1-20 of 57
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5-α reductase inhibitors and prostate cancer prevention: where do we turn now?
(BMC Med, 2011-09-15)With the lifetime risk of being diagnosed with prostate cancer so great, an effective chemopreventive agent could have a profound impact on the lives of men. Despite decades of searching for such an agent, physicians still ... -
A brief history of research synthesis.
(Eval Health Prof, 2002-03)Science is supposed to be cumulative, but scientists only rarely cumulate evidence scientifically. This means that users of research evidence have to cope with a plethora of reports of individual studies with no systematic ... -
A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design.
(Trials, 2014-01)<h4>Background</h4>The proportion of clinical research sponsored by industry will likely continue to expand as federal funds for academic research decreases, particularly in the fields of HIV/AIDS and hepatitis C (HCV). ... -
Adaptive intervention design in mobile health: Intervention design and development in the Cell Phone Intervention for You trial.
(Clin Trials, 2015-12)BACKGROUND/AIMS: The obesity epidemic has spread to young adults, and obesity is a significant risk factor for cardiovascular disease. The prominence and increasing functionality of mobile phones may provide an opportunity ... -
Advances in opioid antagonist treatment for opioid addiction.
(The Psychiatric clinics of North America, 2012-06) -
Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials.
(Psychosom Med, 2010-04)OBJECTIVES: To assess the effects of aerobic exercise training on neurocognitive performance. Although the effects of exercise on neurocognition have been the subject of several previous reviews and meta-analyses, they have ... -
Auriculotherapy for pain management: a systematic review and meta-analysis of randomized controlled trials.
(J Altern Complement Med, 2010-10)OBJECTIVES: Side-effects of standard pain medications can limit their use. Therefore, nonpharmacologic pain relief techniques such as auriculotherapy may play an important role in pain management. Our aim was to conduct ... -
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
(Addiction (Abingdon, England), 2016-12)<h4>Aims</h4>To assess the safety of buprenorphine compared with methadone to treat pregnant women with opioid use disorder.<h4>Methods</h4>We searched PubMed, Embase and the Cochrane Library from inception to February 2015 ... -
Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
(J Policy Anal Manage, 2015)Early interventions are a preferred method for addressing behavioral problems in high-risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve ... -
Caveat emptor: the combined effects of multiplicity and selective reporting.
(Trials, 2018-09-17)Clinical trials and systematic reviews of clinical trials inform healthcare decisions. There is growing concern, however, about results from clinical trials that cannot be reproduced. Reasons for nonreproducibility include ... -
Chronic Lyme disease: the controversies and the science.
(Expert Rev Anti Infect Ther, 2011-07)The diagnosis of chronic Lyme disease has been embroiled in controversy for many years. This is exacerbated by the lack of a clinical or microbiologic definition, and the commonality of chronic symptoms in the general population. ... -
Clinical trials registration.
(PLoS Med, 2006-03) -
Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial.
(American heart journal, 2020-08)Angiotensin-converting enzyme-2 (ACE2) expression may increase due to upregulation in patients using angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs). Because renin-angiotensin system ... -
Does distance modify the effect of self-testing in oral anticoagulation?
(The American journal of managed care, 2016-01)<h4>Objectives</h4>Patient self-testing (PST) improves anticoagulation control and patient satisfaction. It is unknown whether these effects are more pronounced when the patient lives farther from the anticoagulation clinic ... -
Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
(The New England journal of medicine, 2017-06)BACKGROUND:After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. ... -
Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer.
(International journal of cancer, 2018-11)The toll-like receptor (TLR) signaling pathway plays an important role in the innate immune responses and antigen-specific acquired immunity. Aberrant activation of the TLR pathway has a significant impact on carcinogenesis ... -
Homeopathic treatments in psychiatry: a systematic review of randomized placebo-controlled studies.
(J Clin Psychiatry, 2011-06)OBJECTIVE: To systematically review placebo-controlled randomized trials of homeopathy for psychiatric conditions. DATA SOURCES: Eligible studies were identified using the following databases from database inception to April ... -
Identifying treatment effects of an informal caregiver education intervention to increase days in the community and decrease caregiver distress: a machine-learning secondary analysis of subgroup effects in the HI-FIVES randomized clinical trial.
(Trials, 2020-02)<h4>Background</h4>Informal caregivers report substantial burden and depressive symptoms which predict higher rates of patient institutionalization. While caregiver education interventions may reduce caregiver distress and ... -
Improving Veteran Access to Integrated Management of Back Pain (AIM-Back): Protocol for an Embedded Pragmatic Cluster-Randomized Trial.
(Pain medicine (Malden, Mass.), 2020-12)<h4>Background</h4>Coordinated efforts between the National Institutes of Health, the Department of Defense, and the Department of Veterans Affairs have built the capacity for large-scale clinical research investigating ... -
Influence of M. tuberculosis lineage variability within a clinical trial for pulmonary tuberculosis.
(PLoS One, 2010-05-20)Recent studies suggest that M. tuberculosis lineage and host genetics interact to impact how active tuberculosis presents clinically. We determined the phylogenetic lineages of M. tuberculosis isolates from participants ...
