Browsing by Subject "Ras"
Now showing items 1-5 of 5
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Characterization of Drosophila Ctr1a: New Roles for Ctr1 Proteins and Copper in Physiology and Cell Signaling Pathways
(2008-10-21)Copper is an essential trace element required by all aerobic organisms as a co-factor for enzymes involved in normal growth, development and physiology. Ctr1 proteins are members of a highly conserved family of copper importers ... -
Deciphering the Role of the YAP Oncoprotein in Ras-driven Rhabdomyosarcoma Tumorigenesis
(2017)Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children and adolescents, is characterized by skeletal muscle features. The Ras-driven subset, which includes the embryonal (eRMS) and pleomorphic (pRMS) histologic ... -
eIF4E Phosphorylation Balances Cap-dependent and Cap-independent Translation Initiation
(2011)Signaling pathways converge on the translation machinery and influence protein synthesis globally or specifically on certain classes of transcripts. The experiments described in this thesis focus on regulation of translation ... -
Ras Intrinsic and Extrinsic Pathways in Human Cancer
(2008-12-11)The Ras family of proteins, composed of H, N, and KRas, function as small GTPases that act as "molecular switches" relaying signals from the cell membrane to the rest of the cell in a highly regulated manner. However, Ras ... -
The Role of Ral GTPases in Human Oncogenic Transformation
(2009)The genes encoding the Ras family of small GTPases are mutated to yield constitutively active GTP-bound oncoproteins in one-third of all human cancers. In many other cancers lacking Ras mutations, Ras is activated by other ...
