Now showing items 1-3 of 3

    • beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. 

      Kohout, TA; Lin, FS; Perry, SJ; Conner, DA; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 2001-02-13)
      The two widely coexpressed isoforms of beta-arrestin (termed beta arrestin 1 and 2) are highly similar in amino acid sequence. The beta-arrestins bind phosphorylated heptahelical receptors to desensitize and target them ...
    • Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 

      Claing, A; Perry, SJ; Achiriloaie, M; Walker, JK; Albanesi, JP; Lefkowitz, RJ; Premont, RT (Proc Natl Acad Sci U S A, 2000-02-01)
      Recently, we identified a GTPase-activating protein for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1. This protein initially was identified as an interacting partner for the G protein-coupled ...
    • When 7 transmembrane receptors are not G protein-coupled receptors. 

      Rajagopal, Keshava; Lefkowitz, Robert J; Rockman, Howard A (J Clin Invest, 2005-11)
      Classically, 7 transmembrane receptors transduce extracellular signals by coupling to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated that they can also signal via G protein-independent ...