Browsing by Subject "Regeneration"
Now showing items 1-16 of 16
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Activation of developmental signaling pathways in hematopoietic stem cell regeneration
(2010)The homeostatic hematopoietic stem cell compartment is comprised of quiescent long term self renewing stem cells and cycling short term stem cells with finite renewal potential. To study the molecular mechanisms governing ... -
Epidermal growth factor regulates hematopoietic regeneration after radiation injury.
(Nat Med, 2013-03)The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow serum of ... -
Epigenetic Profiling of Zebrafish Fin Regeneration
(2020)The ability to regenerate after injury is quite astonishing, yet not all organisms share this ability. Mammalian genomes likely encode all gene products required to regenerate an amputated limb, yet they lack the correct ... -
Ex vivo expansion of murine and human hematopoietic stem cells
(Methods in Molecular Biology, 2014)Hematopoietic stem cells have the capacity to self-renew and give rise to the entirety of the mature blood and immune system throughout the lifespan of an organism. Here, we describe methods to isolate and culture murine ... -
Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering.
(Tissue Eng Part A, 2010-04)Articular cartilage possesses complex mechanical properties that provide healthy joints the ability to bear repeated loads and maintain smooth articulating surfaces over an entire lifetime. In this study, we utilized ... -
Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration.
(Biomaterials, 2013-10)Cell delivery to the pathological intervertebral disc (IVD) has significant therapeutic potential for enhancing IVD regeneration. The development of injectable biomaterials that retain delivered cells, promote cell survival, ... -
Mechanisms Underlying Bone Cell Recovery During Zebrafish Fin Regeneration
(2013)Zebrafish regenerate amputated caudal fins, restoring the size and shape of the original appendage. Regeneration requires generation of diverse cell types comprising the adult fin tissue. Knowledge of the cellular source ... -
Mechanobiology of the meniscus.
(J Biomech, 2015-06-01)The meniscus plays a critical biomechanical role in the knee, providing load support, joint stability, and congruity. Importantly, growing evidence indicates that the mechanobiologic response of meniscal cells plays a critical ... -
Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish.
(Elife, 2015-04-01)Heart regeneration is limited in adult mammals but occurs naturally in adult zebrafish through the activation of cardiomyocyte division. Several components of the cardiac injury microenvironment have been identified, yet ... -
Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
(Nature communications, 2015-04-13)The plasticity of differentiated cells in adult tissues undergoing repair is an area of intense research. Pulmonary alveolar type II cells produce surfactant and function as progenitors in the adult, demonstrating ... -
Ras controls melanocyte expansion during zebrafish fin stripe regeneration.
(Dis Model Mech, 2010-07)Regenerative medicine for complex tissues like limbs will require the provision or activation of precursors for different cell types, in the correct number, and with the appropriate instructions. These strategies can be ... -
Regulation of Progenitor Cell Proliferation During Zebrafish Fin Regeneration
(2009)Vertebrates like urodele and teleost have an enhanced capacity for regeneration, when compared to mammals. Recently, the teleost zebrafish (Danio rerio) has become a popular model for studying regenerative events, due to ... -
Requirements for Regenerative Mechanisms in Tissue Growth and Homeostasis in Adult Zebrafish
(2009)The teleost zebrafish (danio rerio) has a highly elevated regenerative capacity compared to mammals, with the ability to quickly and correctly regenerate complex organs such as the fin and the heart following amputation. ... -
RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation.
(J Invest Dermatol, 2015-04)Mice with epidermal deletion of JunB transcription factor displayed a psoriasis-like inflammation. The relevance of these findings to humans and the mechanisms mediating JunB function are not fully understood. Here we demonstrate ... -
The Role of Abl Kinases in Lung Injury and Cancer
(2019)Epithelial cells are the organism’s first defensive barrier to pathogens, toxins, and other noxious elements. Constant exposure to these elements requires exquisite control over the process of regeneration to ensure that ... -
The role of stem cells in airway repair: implications for the origins of lung cancer.
(Chin J Cancer, 2013-02)Lung cancer is the leading cause of cancer-related deaths worldwide. Recently, advancements in our ability to identify and study stem cell populations in the lung have helped researchers to elucidate the central role that ...
