Browsing by Subject "Reproducibility of Results"
Now showing items 1-20 of 95
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3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea.
(Opt Express, 2010-04-26)Capable of three-dimensional imaging of the cornea with micrometer-scale resolution, spectral domain-optical coherence tomography (SDOCT) offers potential advantages over Placido ring and Scheimpflug photography based systems ... -
A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples.
(Genome Res, 2014-07)Unbiased next-generation sequencing (NGS) approaches enable comprehensive pathogen detection in the clinical microbiology laboratory and have numerous applications for public health surveillance, outbreak investigation, ... -
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
(PLoS Genet, 2010-02-19)To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase the risk of type 2 diabetes (T2D) in a Han Chinese population. A two-stage genome-wide association (GWA) ... -
A new algorithm for predicting time to disease endpoints in Alzheimer's disease patients.
(J Alzheimers Dis, 2014)BACKGROUND: The ability to predict the length of time to death and institutionalization has strong implications for Alzheimer's disease patients and caregivers, health policy, economics, and the design of intervention studies. ... -
A risk score for in-hospital death in patients admitted with ischemic or hemorrhagic stroke.
(J Am Heart Assoc, 2013-01-28)BACKGROUND: We aimed to derive and validate a single risk score for predicting death from ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). METHODS AND RESULTS: Data from 333 865 stroke ... -
Analytical performance evaluation of the Elecsys® Troponin T Gen 5 STAT assay.
(Clinica chimica acta; international journal of clinical chemistry, 2019-08)BACKGROUND:We report the analytical performance of the Elecsys® Troponin T Gen 5 STAT (TnT Gen 5 STAT; Roche Diagnostics) assay. METHODS:Measuring limits/ranges were determined in lithium-heparin plasma samples per Clinical ... -
Application description and policy model in collaborative environment for sharing of information on epidemiological and clinical research data sets.
(PLoS One, 2010-02-19)BACKGROUND: Sharing of epidemiological and clinical data sets among researchers is poor at best, in detriment of science and community at large. The purpose of this paper is therefore to (1) describe a novel Web application ... -
Association of Common Genetic Polymorphisms with Melanoma Patient IL-12p40 Blood Levels, Risk, and Outcomes.
(J Invest Dermatol, 2015-09)Recent investigation has identified association of IL-12p40 blood levels with melanoma recurrence and patient survival. No studies have investigated associations of single-nucleotide polymorphisms (SNPs) with melanoma patient ... -
Bayesian inference for genomic data integration reduces misclassification rate in predicting protein-protein interactions.
(PLoS Comput Biol, 2011-07)Protein-protein interactions (PPIs) are essential to most fundamental cellular processes. There has been increasing interest in reconstructing PPIs networks. However, several critical difficulties exist in obtaining reliable ... -
Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
(Elife, 2015-01-09)Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering ... -
Caveat emptor: the combined effects of multiplicity and selective reporting.
(Trials, 2018-09-17)Clinical trials and systematic reviews of clinical trials inform healthcare decisions. There is growing concern, however, about results from clinical trials that cannot be reproduced. Reasons for nonreproducibility include ... -
Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler.
(BMC Genomics, 2010-07-21)BACKGROUND: The rate of emergence of human pathogens is steadily increasing; most of these novel agents originate in wildlife. Bats, remarkably, are the natural reservoirs of many of the most pathogenic viruses in humans. ... -
Clinical assessment and characterization of a dual tube kilovoltage X-ray localization system in the radiotherapy treatment room.
(Journal of applied clinical medical physics, 2008-01-13)INTRODUCTION:Although flat-panel based X-ray imaging has been well tested in diagnostic radiology, its use as an image-guided-radiotherapy (IGRT) system in a treatment room is new and requires systematic assessment. MATERIALS ... -
Comparison of interlaboratory variation in absolute T-cell counts by single-platform and optimized dual-platform methods.
(Cytometry B Clin Cytom, 2010-05)BACKGROUND: Previous studies have reported that the adoption of a single-platform flow cytometry cell counting method resulted in lower interlaboratory variation in absolute T cell counts as compared to predicate dual-platform ... -
Cost-effectiveness analysis of the diagnosis of meniscus tears.
(Am J Sports Med, 2015-01)BACKGROUND: Diagnostic imaging represents the fastest growing segment of costs in the US health system. This study investigated the cost-effectiveness of alternative diagnostic approaches to meniscus tears of the knee, a ... -
Delivery efficiency of an Elekta linac under gated operation.
(Journal of applied clinical medical physics, 2014-09-08)In this study, we have characterized the efficiency of an Elekta linac in the delivery of gated radiotherapy. We have explored techniques to reduce the beam-on delay and to improve the delivery efficiency, and have investigated ... -
Design of the NIDA clinical trials network validation study of tobacco, alcohol, prescription medications, and substance use/misuse (TAPS) tool.
(Contemporary clinical trials, 2016-09)Substance use and its associated use disorders are under-detected and under-treated in primary care. There is a need for a clinically useful brief screening and assessment instrument to identify primary care patients with ... -
Detection of depression in low resource settings: validation of the Patient Health Questionnaire (PHQ-9) and cultural concepts of distress in Nepal.
(BMC Psychiatry, 2016-03-08)BACKGROUND: Despite recognition of the burden of disease due to mood disorders in low- and middle-income countries, there is a lack of consensus on best practices for detecting depression. Self-report screening tools, such ... -
Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays.
(J Immunol Methods, 2014-07)Luminex bead array assays are widely used for rapid biomarker quantification due to the ability to measure up to 100 unique analytes in a single well of a 96-well plate. There has been, however, no comprehensive analysis ... -
Development of a contemporary globally diverse HIV viral panel by the EQAPOL program.
(J Immunol Methods, 2014-07)The significant diversity among HIV-1 variants poses serious challenges for vaccine development and for developing sensitive assays for screening, surveillance, diagnosis, and clinical management. Recognizing a need to develop ...
