Browsing by Subject "Retinal Cone Photoreceptor Cells"
Now showing items 1-11 of 11
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Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats.
(Journal of neurophysiology, 2017-07)We have determined the impact of rod death and cone reorganization on the spatiotemporal receptive fields (RFs) and spontaneous activity of distinct retinal ganglion cell (RGC) types. We compared RGC function between healthy ... -
Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones.
(Cellular and molecular life sciences : CMLS, 2023-07)Mutations in the photoreceptor-specific tetraspanin gene peripherin-2 (PRPH2) lead to widely varying forms of retinal degeneration ranging from retinitis pigmentosa to macular dystrophy. Both inter- and intra-familial phenotypic ... -
Correlated firing among major ganglion cell types in primate retina.
(The Journal of physiology, 2011-01)Retinal ganglion cells exhibit substantial correlated firing: a tendency to fire nearly synchronously at rates different from those expected by chance. These correlations suggest that network interactions significantly shape ... -
Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
(PLoS Genet, 2013-06)Non-autonomous cell-death is a cardinal feature of the disintegration of neural networks in neurodegenerative diseases, but the molecular bases of this process are poorly understood. The neural retina comprises a mosaic ... -
Efficient coding of spatial information in the primate retina.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012-11)Sensory neurons have been hypothesized to efficiently encode signals from the natural environment subject to resource constraints. The predictions of this efficient coding hypothesis regarding the spatial filtering properties ... -
Functional connectivity in the retina at the resolution of photoreceptors.
(Nature, 2010-10)To understand a neural circuit requires knowledge of its connectivity. Here we report measurements of functional connectivity between the input and ouput layers of the macaque retina at single-cell resolution and the implications ... -
High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina.
(Nat Neurosci, 2009-09)Small bistratified cells (SBCs) in the primate retina carry a major blue-yellow opponent signal to the brain. We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input. SBCs exhibited ... -
Mapping nonlinear receptive field structure in primate retina at single cone resolution.
(eLife, 2015-10-30)The function of a neural circuit is shaped by the computations performed by its interneurons, which in many cases are not easily accessible to experimental investigation. Here, we elucidate the transformation of visual signals ... -
Monte Carlo methods for localization of cones given multielectrode retinal ganglion cell recordings.
(Network (Bristol, England), 2013-01)It has recently become possible to identify cone photoreceptors in primate retina from multi-electrode recordings of ganglion cell spiking driven by visual stimuli of sufficiently high spatial resolution. In this paper we ... -
Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina.
(PLoS biology, 2019-04)The stream of visual information sent from photoreceptors to second-order bipolar cells is intercepted by laterally interacting horizontal cells that generate feedback to optimize and improve the efficiency of signal ... -
Retinal representation of the elementary visual signal.
(Neuron, 2014-01)The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording ...
