Now showing items 1-16 of 16

    • A polyaxonal amacrine cell population in the primate retina. 

      Greschner, Martin; Field, Greg D; Li, Peter H; Schiff, Max L; Gauthier, Jeffrey L; Ahn, Daniel; Sher, Alexander; ... (9 authors) (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014-03)
      Amacrine cells are the most diverse and least understood cell class in the retina. Polyaxonal amacrine cells (PACs) are a unique subset identified by multiple long axonal processes. To explore their functional properties, ...
    • Anatomical identification of extracellularly recorded cells in large-scale multielectrode recordings. 

      Li, Peter H; Gauthier, Jeffrey L; Schiff, Max; Sher, Alexander; Ahn, Daniel; Field, Greg D; Greschner, Martin; ... (10 authors) (J Neurosci, 2015-03-18)
      This study combines for the first time two major approaches to understanding the function and structure of neural circuits: large-scale multielectrode recordings, and confocal imaging of labeled neurons. To achieve this ...
    • Calcineurin activation causes retinal ganglion cell degeneration. 

      Qu, Juan; Matsouaka, Roland; Betensky, Rebecca A; Hyman, Bradley T; Grosskreutz, Cynthia L (Mol Vis, 2012)
      PURPOSE: We previously reported that calcineurin, a Ca(2+)/calmodulin-dependent serine/threonine phosphatase, is activated and proposed that it participates in retinal ganglion cell (RGC) apoptosis in two rodent ...
    • Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats. 

      Yu, Wan-Qing; Grzywacz, Norberto M; Lee, Eun-Jin; Field, Greg D (Journal of neurophysiology, 2017-07)
      We have determined the impact of rod death and cone reorganization on the spatiotemporal receptive fields (RFs) and spontaneous activity of distinct retinal ganglion cell (RGC) types. We compared RGC function between healthy ...
    • Correlated firing among major ganglion cell types in primate retina. 

      Greschner, Martin; Shlens, Jonathon; Bakolitsa, Constantina; Field, Greg D; Gauthier, Jeffrey L; Jepson, Lauren H; Sher, Alexander; ... (9 authors) (The Journal of physiology, 2011-01)
      Retinal ganglion cells exhibit substantial correlated firing: a tendency to fire nearly synchronously at rates different from those expected by chance. These correlations suggest that network interactions significantly shape ...
    • Efficient coding of spatial information in the primate retina. 

      Doi, Eizaburo; Gauthier, Jeffrey L; Field, Greg D; Shlens, Jonathon; Sher, Alexander; Greschner, Martin; Machado, Timothy A; ... (14 authors) (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012-11)
      Sensory neurons have been hypothesized to efficiently encode signals from the natural environment subject to resource constraints. The predictions of this efficient coding hypothesis regarding the spatial filtering properties ...
    • Functional connectivity in the retina at the resolution of photoreceptors. 

      Field, Greg D; Gauthier, Jeffrey L; Sher, Alexander; Greschner, Martin; Machado, Timothy A; Jepson, Lauren H; Shlens, Jonathon; ... (13 authors) (Nature, 2010-10)
      To understand a neural circuit requires knowledge of its connectivity. Here we report measurements of functional connectivity between the input and ouput layers of the macaque retina at single-cell resolution and the implications ...
    • Global Motion Processing by Populations of Direction-Selective Retinal Ganglion Cells. 

      Cafaro, Jon; Zylberberg, Joel; Field, Greg D (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020-07)
      Simple stimuli have been critical to understanding neural population codes in sensory systems. Yet it remains necessary to determine the extent to which this understanding generalizes to more complex conditions. To examine ...
    • High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina. 

      Field, Greg D; Greschner, Martin; Gauthier, Jeffrey L; Rangel, Carolina; Shlens, Jonathon; Sher, Alexander; Marshak, David W; ... (9 authors) (Nat Neurosci, 2009-09)
      Small bistratified cells (SBCs) in the primate retina carry a major blue-yellow opponent signal to the brain. We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input. SBCs exhibited ...
    • Ignoring correlated activity causes a failure of retinal population codes. 

      Ruda, Kiersten; Zylberberg, Joel; Field, Greg D (Nature communications, 2020-09-14)
      From starlight to sunlight, adaptation alters retinal output, changing both the signal and noise among populations of retinal ganglion cells (RGCs). Here we determine how these light level-dependent changes impact decoding ...
    • Monte Carlo methods for localization of cones given multielectrode retinal ganglion cell recordings. 

      Sadeghi, K; Gauthier, JL; Field, GD; Greschner, M; Agne, M; Chichilnisky, EJ; Paninski, L (Network (Bristol, England), 2013-01)
      It has recently become possible to identify cone photoreceptors in primate retina from multi-electrode recordings of ganglion cell spiking driven by visual stimuli of sufficiently high spatial resolution. In this paper we ...
    • Nogo receptor 1 is expressed by nearly all retinal ganglion cells. 

      Solomon, Alexander M; Westbrook, Teleza; Field, Greg D; McGee, Aaron W (PloS one, 2018-01)
      A variety of conditions ranging from glaucoma to blunt force trauma lead to optic nerve atrophy. Identifying signaling pathways for stimulating axon growth in the optic nerve may lead to treatments for these pathologies. ...
    • Pathway-Specific Asymmetries between ON and OFF Visual Signals. 

      Ravi, Sneha; Ahn, Daniel; Greschner, Martin; Chichilnisky, EJ; Field, Greg D (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018-11)
      Visual processing is largely organized into ON and OFF pathways that signal stimulus increments and decrements, respectively. These pathways exhibit natural pairings based on morphological and physiological similarities, ...
    • Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids. 

      VanderWall, Kirstin B; Huang, Kang-Chieh; Pan, Yanling; Lavekar, Sailee S; Fligor, Clarisse M; Allsop, Anna R; Lentsch, Kelly A; ... (12 authors) (Stem cell reports, 2020-07)
      Retinal ganglion cells (RGCs) serve as the connection between the eye and the brain, with this connection disrupted in glaucoma. Numerous cellular mechanisms have been associated with glaucomatous neurodegeneration, and ...
    • Retinal representation of the elementary visual signal. 

      Li, Peter H; Field, Greg D; Greschner, Martin; Ahn, Daniel; Gunning, Deborah E; Mathieson, Keith; Sher, Alexander; ... (9 authors) (Neuron, 2014-01)
      The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording ...
    • "Silent" NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit. 

      Sethuramanujam, Santhosh; Yao, Xiaoyang; deRosenroll, Geoff; Briggman, Kevin L; Field, Greg D; Awatramani, Gautam B (Neuron, 2017-12)
      Retinal direction-selective ganglion cells (DSGCs) have the remarkable ability to encode motion over a wide range of contrasts, relying on well-coordinated excitation and inhibition (E/I). E/I is orchestrated by a diverse ...