Browsing by Subject "SARS-CoV-2"
Now showing items 1-20 of 75
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A genetically engineered, stem-cell-derived cellular vaccine.
(Cell reports. Medicine, 2022-12)Despite rapid clinical translation of COVID-19 vaccines in response to the global pandemic, an opportunity remains for vaccine technology innovation to address current limitations and meet challenges of inevitable future ... -
Activity of Galidesivir in a Hamster Model of SARS-CoV-2.
(Viruses, 2021-12-21)Coronavirus disease 2019 (COVID-19) has claimed the lives of millions of people worldwide since it first emerged. The impact of the COVID-19 pandemic on public health and the global economy has highlighted the medical need ... -
An Agile Systems Modeling Framework for Bed Resource Planning During COVID-19 Pandemic in Singapore.
(Frontiers in public health, 2022-01)<h4>Background</h4>The COVID-19 pandemic has had a major impact on health systems globally. The sufficiency of hospitals' bed resource is a cornerstone for access to care which can significantly impact the public health ... -
An Analysis of Public Interest in Elective Neurosurgical Procedures During the COVID-19 Pandemic Through Online Search Engine Trends.
(World neurosurgery, 2021-04)<h4>Objective</h4>In the wake of the COVID-19 pandemic, the Centers for Medicare & Medicaid Services (CMS) has recommended the temporary cessation of all elective surgeries. The effects on patients' interest of elective ... -
An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.
(Genome medicine, 2021-05)<h4>Background</h4>While genome-wide associations studies (GWAS) have successfully elucidated the genetic architecture of complex human traits and diseases, understanding mechanisms that lead from genetic variation ... -
An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral.
(Antiviral research, 2021-09-20)Galidesivir (BCX4430) is an adenosine nucleoside analog that is broadly active in cell culture against several RNA viruses of various families. This activity has also been shown in animal models of viral disease associated ... -
Bilateral anterior and intermediate uveitis in SARS-CoV-2 associated multisystem inflammatory syndrome in a pediatric patient.
(Pediatric rheumatology online journal, 2022-07)<h4>Purpose</h4>To report a case of bilateral anterior intermediate uveitis after recovery from SARS-CoV-2 associated multisystem inflammatory syndrome in children (MIS-C).<h4>Case report</h4>A 9-year-old male presented ... -
Caring for Caregivers During COVID-19.
(Journal of the American Geriatrics Society, 2020-10) -
Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome.
(Stem cells translational medicine, 2020-09)Severe cases of COVID-19 infection, often leading to death, have been associated with variants of acute respiratory distress syndrome (ARDS). Cell therapy with mesenchymal stromal cells (MSCs) is a potential treatment for ... -
Changing trends in mortality among solid organ transplant recipients hospitalized for COVID-19 during the course of the pandemic.
(American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2022-01)Mortality among patients hospitalized for COVID-19 has declined over the course of the pandemic. Mortality trends specifically in solid organ transplant recipients (SOTR) are unknown. Using data from a multicenter registry ... -
Combating Respiratory RNA Viruses with Adaptable Tools and Innate Host Defenses
(2022)In the 21st century, the world has already experienced two pandemics caused by respiratory RNA viruses, the 2009 H1N1 “swine-flu” pandemic, and the ongoing COVID-19 pandemic. The 2009 pandemic was, thankfully, mild in terms ... -
Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial.
(American heart journal, 2020-08)Angiotensin-converting enzyme-2 (ACE2) expression may increase due to upregulation in patients using angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs). Because renin-angiotensin system ... -
Coronavirus Disease 2019-Associated Invasive Fungal Infection.
(Open forum infectious diseases, 2021-12)Coronavirus disease 2019 (COVID-19) can become complicated by secondary invasive fungal infections (IFIs), stemming primarily from severe lung damage and immunologic deficits associated with the virus or immunomodulatory ... -
COVID-19 and the need for disability conscious medical education, training, and practice.
(Journal of pediatric rehabilitation medicine, 2020-01)The COVID-19 era exposes what was already a crisis in the medical profession: structural racism, ageism, sexism, classism, and ableism resulting in healthcare disparities for Persons with Disabilities (PWD). Early research ... -
COVID-19-associated brief psychotic disorder.
(BMJ case reports, 2020-08-11)A 36-year-old previously healthy woman with no personal or family history of mental illness presented with new-onset psychosis after a diagnosis of symptomatic COVID-19. Her psychotic symptoms initially improved ... -
COVID-19-Associated Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications.
(SN comprehensive clinical medicine, 2020-11-21)The concurrence of COVID-19 with Guillain-Barre syndrome (GBS) can increase the likelihood of neuromuscular respiratory failure, autonomic dysfunction, and other life-threatening symptoms. Currently, very little is known ... -
COVID-19-Lessons Learned and Questions Remaining.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-06)In this article, the editors of Clinical Infectious Diseases review some of the most important lessons they have learned about the epidemiology, clinical features, diagnosis, treatment and prevention of SARS-CoV-2 infection ... -
COVID-19: The Time for Collaboration Between Long-Term Services and Supports, Health Care Systems, and Public Health Is Now.
(The Milbank quarterly, 2021-06)Policy Points To address systemic problems amplified by COVID-19, we need to restructure US long-term services and supports (LTSS) as they relate to both the health care systems and public health systems. We present both ... -
Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance.
(The Lancet. Infectious diseases, 2021-06)Severe acute respiratory syndrome coronavirus 2 causes direct damage to the airway epithelium, enabling aspergillus invasion. Reports of COVID-19-associated pulmonary aspergillosis have raised concerns about it worsening ...
