Browsing by Subject "Spinal Cord"
Now showing items 1-20 of 21
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Adaptive stereotactic body radiation therapy planning for lung cancer.
(Int J Radiat Oncol Biol Phys, 2013-09-01)PURPOSE: To investigate the dosimetric effects of adaptive planning on lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Forty of 66 consecutive lung SBRT patients were selected for a retrospective ... -
Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice.
(Journal of the American Heart Association, 2018-09)Background The mechanisms underlying worse outcome at advanced age after cardiac arrest ( CA ) and resuscitation are not well understood. Because protein homeostasis (proteostasis) is essential for cellular and organismal ... -
Association of an axonally transported polypeptide (H) with 100-A filaments. Use of immunoaffinity electron microscope grids.
(The Journal of cell biology, 1980-06)Polypeptide H (mol wt 195,000) is axonally transported in rabbit retinal ganglion cells at a velocity of 0.7--1.1 mm/d, i.e., in the most slowly moving of the five transport groups described in these neurons. To identify ... -
Association of myelopathy scores with cervical sagittal balance and normalized spinal cord volume: analysis of 56 preoperative cases from the AOSpine North America Myelopathy study.
(Spine, 2013-10)<h4>Study design</h4>Post hoc analysis of prospectively collected data.<h4>Objective</h4>Development of methods to determine in vivo spinal cord dimensions and application to correlate preoperative alignment, myelopathy, ... -
Baseline Patient-Reported Outcomes Correlate Weakly With Radiographic Parameters: A Multicenter, Prospective NIH Adult Symptomatic Lumbar Scoliosis Study of 286 Patients.
(Spine, 2016-11)<h4>Study design</h4>Prospective, cross-sectional study.<h4>Objective</h4>The aim of the study was to determine which radiographic parameters drive patient-reported outcomes (PROs) in primary presentation adult symptomatic ... -
CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery.
(Neuroscience letters, 2015-06)Increased matrix metalloproteinase (MMP) activity contributes to glial scar formation that inhibits the repair path after spinal cord injury (SCI). We examined whether treatment with N-(2-chloroethyl)-5Z,8Z,11Z,14Z... -
Development of a simplified spinal cord ischemia model in mice.
(Journal of neuroscience methods, 2010-06)Use of genetically manipulated mice facilitates understanding pathological mechanisms in many diseases and contributes to therapy development. However, there is no practical and clinically relevant mouse model available ... -
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
(J Neurosci, 2002-12-01)Morphine induces antinociception by activating mu opioid receptors (muORs) in spinal and supraspinal regions of the CNS. (Beta)arrestin-2 (beta)arr2), a G-protein-coupled receptor-regulating protein, regulates the muOR in ... -
Evaluation of intradural stimulation efficiency and selectivity in a computational model of spinal cord stimulation.
(PloS one, 2014-01)Spinal cord stimulation (SCS) is an alternative or adjunct therapy to treat chronic pain, a prevalent and clinically challenging condition. Although SCS has substantial clinical success, the therapy is still prone to failures, ... -
Examination of Adult Spinal Deformity Patients Undergoing Surgery with Implanted Spinal Cord Stimulators and Intrathecal Pumps.
(Spine, 2022-02)<h4>Study design</h4>Retrospective cohort study of a prospectively collected multi-center database of adult spinal deformity (ASD) patients.<h4>Objective</h4>We hypothesized that patients undergoing ASD surgery with and ... -
Expert's comment concerning grand rounds case entitled "surgical treatment of a 180° thoracolumbar fixed kyphosis in a young achondroplastic patient: a one stage 'in situ' combined fusion and spinal cord translocation" (by J. C. Aurégan, T. Odent, M. Zerah, J.-P. Padovani and C. Glorion).
(European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2010-11)An expert comment is provided for the case of an 18-year-old male achondroplastic patient with a severe thoracolumbar kyphosis and spinal stenosis managed with a five level hemilaminotomy, a decancellation osteotomy of the ... -
Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.
(J Clin Invest, 2010-05)The folate pathway plays a crucial role in the regeneration and repair of the adult CNS after injury. Here, we have shown in rodents that such repair occurs at least in part through DNA methylation. In animals with combined ... -
Intraoperative electrophysiological monitoring in spine surgery.
(Spine, 2010-12)<h4>Study design</h4>Review of the literature with analysis of pooled data.<h4>Objective</h4>To assess common intraoperative neuromonitoring (IOM) changes that occur during the course of spinal surgery, potential causes ... -
Introduction: Adult spinal deformity: pathophysiology and corrective measures.
(Neurosurgical focus, 2014-05) -
Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain.
(Mol Pain, 2015-04-10)BACKGROUND: Mechanical and in particular tactile allodynia is a hallmark of chronic pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based neural tracing experiments and electrophysiology studies ... -
Natural History, Predictors of Outcome, and Effects of Treatment in Thoracic Spinal Cord Injury: A Multi-Center Cohort Study from the North American Clinical Trials Network.
(Journal of neurotrauma, 2018-11)The course, treatment response, and recovery potential after acute traumatic spinal cord injury (SCI) have been shown to differ depending on the neurological level of injury. There are limited data focused on thoracic-level ... -
Neuroanesthesia Guidelines for Optimizing Transcranial Motor Evoked Potential Neuromonitoring During Deformity and Complex Spinal Surgery: A Delphi Consensus Study.
(Spine, 2020-07)<h4>Study design</h4>Expert opinion-modified Delphi study.<h4>Objective</h4>We used a modified Delphi approach to obtain consensus among leading spinal deformity surgeons and their neuroanesthesiology teams regarding optimal ... -
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
(J Neurosci, 2004-05-12)Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation (pSNL) is known to contribute to the neuropathic pain processes. Using a phosphoselective antibody [kappa opioid receptor ... -
Predictive Modeling of Length of Hospital Stay Following Adult Spinal Deformity Correction: Analysis of 653 Patients with an Accuracy of 75% within 2 Days.
(World neurosurgery, 2018-07)Length of stay (LOS) after surgery for adult spinal deformity (ASD) is a critical period that allows for optimal recovery. Predictive models that estimate LOS allow for stratification of high-risk patients.A prospectively ... -
Predictors of pulmonary complications in blunt traumatic spinal cord injury.
(Journal of neurosurgery. Spine, 2012-09)<h4>Object</h4>Pulmonary complications are the most common acute systemic adverse events following spinal cord injury (SCI), and contribute to morbidity, mortality, and increased length of hospital stay (LOS). Identification ...
