Now showing items 1-10 of 10

    • HPV clearance and the neglected role of stochasticity. 

      Ryser, MD; Myers, ER; Durrett, R (PLoS Comput Biol, 2015-03)
      Clearance of anogenital and oropharyngeal HPV infections is attributed primarily to a successful adaptive immune response. To date, little attention has been paid to the potential role of stochastic cell dynamics in the ...
    • Inference for nonlinear epidemiological models using genealogies and time series. 

      Rasmussen, David A; Ratmann, Oliver; Koelle, Katia (PLoS Comput Biol, 2011-08)
      Phylodynamics - the field aiming to quantitatively integrate the ecological and evolutionary dynamics of rapidly evolving populations like those of RNA viruses - increasingly relies upon coalescent approaches to infer past ...
    • Low demographic variability in wild primate populations: fitness impacts of variation, covariation, and serial correlation in vital rates. 

      Morris, William F; Altmann, Jeanne; Brockman, Diane K; Cords, Marina; Fedigan, Linda M; Pusey, Anne E; Stoinski, Tara S; ... (10 authors) (Am Nat, 2011-01)
      In a stochastic environment, long-term fitness can be influenced by variation, covariation, and serial correlation in vital rates (survival and fertility). Yet no study of an animal population has parsed the contributions ...
    • Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts. 

      Akushevich, Igor V; Veremeyeva, Galina A; Dimov, Georgy P; Ukraintseva, Svetlana V; Arbeev, Konstantin G; Akleyev, Alexander V; Yashin, Anatoly I (Health Phys, 2010-09)
      A new model of the hematopoietic system for humans chronically exposed to ionizing radiation allows for quantitative description of the initial hematopoiesis inhibition and subsequent increase in the risks of late stochastic ...
    • Modeling hematopoietic system response caused by chronic exposure to ionizing radiation. 

      Akushevich, Igor V; Veremeyeva, Galina A; Dimov, Georgy P; Ukraintseva, Svetlana V; Arbeev, Konstantin G; Akleyev, Alexander V; Yashin, Anatoly I (Radiat Environ Biophys, 2011-05)
      A new model of the hematopoietic system response in humans chronically exposed to ionizing radiation describes the dynamics of the hematopoietic stem cell compartment as well as the dynamics of each of the four blood cell ...
    • New stochastic carcinogenesis model with covariates: an approach involving intracellular barrier mechanisms. 

      Akushevich, Igor; Veremeyeva, Galina; Kravchenko, Julia; Ukraintseva, Svetlana; Arbeev, Konstantin; Akleyev, Alexander V; Yashin, Anatoly I (Math Biosci, 2012-03)
      In this paper we present a new multiple-pathway stochastic model of carcinogenesis with potential of predicting individual incidence risks on the basis of biomedical measurements. The model incorporates the concept ...
    • Non-neutral vegetation dynamics. 

      Marani, M; Zillio, T; Belluco, E; Silvestri, S; Maritan, A (PLoS One, 2006-12-20)
      The neutral theory of biodiversity constitutes a reference null hypothesis for the interpretation of ecosystem dynamics and produces relatively simple analytical descriptions of basic system properties, which can be easily ...
    • Phylodynamic inference for structured epidemiological models. 

      Rasmussen, David A; Volz, Erik M; Koelle, Katia (PLoS Comput Biol, 2014-04)
      Coalescent theory is routinely used to estimate past population dynamics and demographic parameters from genealogies. While early work in coalescent theory only considered simple demographic models, advances in theory have ...
    • Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators. 

      Karapetyan, Sargis; Buchler, Nicolas E (Phys Rev E Stat Nonlin Soft Matter Phys, 2015-12)
      Genetic oscillators, such as circadian clocks, are constantly perturbed by molecular noise arising from the small number of molecules involved in gene regulation. One of the strongest sources of stochasticity is the binary ...
    • Stochastic E2F activation and reconciliation of phenomenological cell-cycle models. 

      Lee, Tae J; Yao, Guang; Bennett, Dorothy C; Nevins, Joseph R; You, Lingchong (PLoS Biol, 2010-09-21)
      The transition of the mammalian cell from quiescence to proliferation is a highly variable process. Over the last four decades, two lines of apparently contradictory, phenomenological models have been proposed to account ...