Browsing by Subject "Stroke"
Now showing items 1-20 of 110
-
A mathematical model for persistent post-CSD vasoconstriction.
(PLoS computational biology, 2020-07-15)Cortical spreading depression (CSD) is the propagation of a relatively slow wave in cortical brain tissue that is linked to a number of pathological conditions such as stroke and migraine. Most of the existing literature ... -
A risk score for in-hospital death in patients admitted with ischemic or hemorrhagic stroke.
(J Am Heart Assoc, 2013-01-28)BACKGROUND: We aimed to derive and validate a single risk score for predicting death from ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). METHODS AND RESULTS: Data from 333 865 stroke ... -
Absence of July Phenomenon in Acute Ischemic Stroke Care Quality and Outcomes.
(Journal of the American Heart Association, 2018-01-31)BACKGROUND:Lower care quality and an increase in adverse outcomes as a result of new medical trainees is a concept well rooted in popular belief, termed the "July phenomenon." Whether this phenomenon occurs in acute ischemic ... -
Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015.
(J Am Heart Assoc, 2015-11-05)BACKGROUND: A 1.5-day interactive forum was convened to discuss critical issues in the acquisition, analysis, and sharing of data in the field of cardiovascular and stroke science. The discussion will serve as the foundation ... -
Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.
(Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017-03)Impaired function of the endoplasmic reticulum (ER stress) is a hallmark of many human diseases including stroke. To restore ER function in stressed cells, the unfolded protein response (UPR) is induced, which activates ... -
Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study.
(Stem cells translational medicine, 2018-07)Stroke is a major cause of death and long-term disability, affecting one in six people worldwide. The only currently available approved pharmacological treatment for ischemic stroke is tissue plasminogen activator; however, ... -
Anesthesia in Experimental Stroke Research.
(Translational stroke research, 2016-10)Anesthetics have enabled major advances in development of experimental models of human stroke. Yet, their profound pharmacologic effects on neural function can confound the interpretation of experimental stroke research. ... -
Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry.
(Journal of the American Heart Association, 2016-09-28)The extent to which angina is associated with future cardiovascular events in patients with coronary artery disease has long been debated.Included were outpatients with established coronary artery disease who were enrolled ... -
Anticoagulation in Acute Neurological Disease.
(Seminars in neurology, 2021-10)While anticoagulation and its reversal have been of clinical relevance for decades, recent academic and technological advances have expanded the repertoire of its application in neurological disease. The advent of direct ... -
Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass.
(Anesthesia and analgesia, 2010-07)<h4>Background</h4>Aprotinin, a nonspecific serine protease inhibitor, has been used to decrease bleeding and reduce the systemic inflammatory response after cardiopulmonary bypass (CPB). Studies have variably linked aprotinin ... -
Are Periventricular Lesions Specific for Multiple Sclerosis?
(J Neurol Neurophysiol, 2013-05-03)BACKGROUND: The presence of periventricular lesions (PVL) on MRI scans is part of the revised McDonald multiple sclerosis (MS) diagnostic criteria. However, PVL can be found in other neurological diseases including stroke ... -
Association between stroke center hospitalization for acute ischemic stroke and mortality.
(JAMA, 2011-01)Although stroke centers are widely accepted and supported, little is known about their effect on patient outcomes.To examine the association between admission to stroke centers for acute ischemic stroke and mortality.Obs... -
Association Between Thrombolytic Door-to-Needle Time and 1-Year Mortality and Readmission in Patients With Acute Ischemic Stroke.
(JAMA, 2020-06)Importance:Earlier administration of intravenous tissue plasminogen activator (tPA) in acute ischemic stroke is associated with reduced mortality by the time of hospital discharge and better functional outcomes at 3 months. ... -
Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice.
(JAMA, 2019-07)Importance:Randomized clinical trials suggest benefit of endovascular-reperfusion therapy for large vessel occlusion in acute ischemic stroke (AIS) is time dependent, but the extent to which it influences outcome ... -
Association of body mass index with mortality and functional outcome after acute ischemic stroke.
(Scientific reports, 2017-05-31)The relation between obesity and stroke outcome has been disputed. This study was aimed to determine the association of body mass index (BMI) with mortality and functional outcome in patients with acute ischemic stroke. ... -
Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation.
(JAMA, 2017-03)Importance:Antithrombotic therapies are known to prevent stroke for patients with atrial fibrillation (AF) but are often underused in community practice. Objectives:To examine the prevalence of patients with acute ischemic ... -
Automated multimodal segmentation of acute ischemic stroke lesions on clinical MR images.
(Magnetic resonance imaging, 2022-10)Magnetic resonance (MR) imaging (MRI) is commonly used to diagnose, assess and monitor stroke. Accurate and timely segmentation of stroke lesions provides the anatomico-structural information that can aid physicians in predicting ... -
Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation.
(European heart journal, 2023-01)<h4>Aims</h4>Biomarkers specifically related to atrial tissue may increase the understanding of the pathophysiology of atrial fibrillation (AF) and further improve risk prediction in this setting. Bone morphogenetic protein ... -
Bundled Payment and Care of Acute Stroke: What Does it Take to Make it Work?
(Stroke, 2015-05) -
Can acute clinical outcomes predict health-related quality of life after stroke: a one-year prospective study of stroke survivors.
(Health and quality of life outcomes, 2018-11-21)<h4>Background</h4>Health-related quality of life (HRQoL) is a key metric to understand the impact of stroke from patients' perspective. Yet HRQoL is not readily measured in clinical practice. This study aims to investigate ...
