Browsing by Subject "Swine"
Now showing items 1-16 of 16
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An isolated working heart system for large animal models.
(J Vis Exp, 2014-06-11)Since its introduction in the late 19(th) century, the Langendorff isolated heart perfusion apparatus, and the subsequent development of the working heart model, have been invaluable tools for studying cardiovascular function ... -
An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs.
(Science translational medicine, 2020-04)Cell therapy has been a promising strategy for cardiac repair after injury or infarction; however, low retention and engraftment of transplanted cells limit potential therapeutic efficacy. Seeding scaffold material with ... -
Cardiac cell-integrated microneedle patch for treating myocardial infarction.
(Science advances, 2018-11)We engineered a microneedle patch integrated with cardiac stromal cells (MN-CSCs) for therapeutic heart regeneration after acute myocardial infarction (MI). To perform cell-based heart regeneration, cells are currently delivered ... -
Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs.
(ACS biomaterials science & engineering, 2020-11)The vascularized cardiac patch strategy is promising for ischemic heart repair after myocardial infarction (MI), but current fabrication processes are quite complicated. Vascularized cardiac patches that can promote concurrent ... -
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ... -
Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration.
(Anal Chem, 2010-11-01)Surgery is one of the most effective and widely used procedures in treating human cancers, but a major problem is that the surgeon often fails to remove the entire tumor, leaving behind tumor-positive margins, metastatic ... -
Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc.
(J Orthop Res, 2013-10)The extracellular matrix (ECM) of the human intervertebral disc is rich in molecules that interact with cells through integrin-mediated attachments. Porcine nucleus pulposus (NP) cells have been shown to interact with laminin ... -
Intracardiac acoustic radiation force impulse (ARFI) and shear wave imaging in pigs with focal infarctions.
(IEEE Trans Ultrason Ferroelectr Freq Control, 2013-08)Four pigs, three with focal infarctions in the apical intraventricular septum (IVS) and/or left ventricular free wall (LVFW), were imaged with an intracardiac echocardiography (ICE) transducer. Custom beam sequences were ... -
Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery.
(Opt Lett, 2010-10-15)We demonstrate in vivo human retinal imaging using an intraoperative microscope-mounted optical coherence tomography system (MMOCT). Our optomechanical design adapts an Oculus Binocular Indirect Ophthalmo Microscope (BIOM3), ... -
Measurement of intracellular strain on deformable substrates with texture correlation.
(J Biomech, 2007)Mechanical stimuli are important factors that regulate cell proliferation, survival, metabolism and motility in a variety of cell types. The relationship between mechanical deformation of the extracellular matrix ... -
Porcine endothelial cells cocultured with smooth muscle cells became procoagulant in vitro.
(Tissue Eng Part A, 2010-06)Endothelial cell (EC) seeding represents a promising approach to provide a nonthrombogenic surface on vascular grafts. In this study, we used a porcine EC/smooth muscle cell (SMC) coculture model that was previously developed ... -
Safety and efficacy of intravesical chemotherapy and hyperthermia in the bladder: results of a porcine study.
(International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2020-01)<h4>Background</h4>Hyperthermia (heating to 43 °C) activates the innate immune system and improves bladder cancer chemosensitivity.<h4>Objective</h4>To evaluate the tissue penetration and safety of convective hyperthermia ... -
Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels.
(Sci Rep, 2015-10-12)Tissue-engineered blood vessels (TEBV) can serve as vascular grafts and may also play an important role in the development of organs-on-a-chip. Most TEBV construction involves scaffolding with biomaterials such as collagen ... -
Thermodynamic analysis of a molecular chaperone binding to unfolded protein substrates.
(Biochemistry, 2010-02-16)Molecular chaperones are a highly diverse group of proteins that recognize and bind unfolded proteins to facilitate protein folding and prevent nonspecific protein aggregation. The mechanisms by which chaperones bind their ... -
Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.
(Advances in experimental medicine and biology, 2017-01)We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, flexible, tissue-like, biocompatible hydrogel s that have ... -
Transsynaptic Tracing from Peripheral Targets with Pseudorabies Virus Followed by Cholera Toxin and Biotinylated Dextran Amines Double Labeling.
(J Vis Exp, 2015-09-14)Transsynaptic tracing has become a powerful tool used to analyze central efferents that regulate peripheral targets through multi-synaptic circuits. This approach has been most extensively used in the brain by utilizing ...
