Now showing items 1-20 of 23

    • A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. 

      Clopath, Claudia; Badura, Aleksandra; De Zeeuw, Chris I; Brunel, Nicolas (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014-05)
      Mechanisms of cerebellar motor learning are still poorly understood. The standard Marr-Albus-Ito theory posits that learning involves plasticity at the parallel fiber to Purkinje cell synapses under control of the climbing ...
    • A craniofacial-specific monosynaptic circuit enables heightened affective pain. 

      Rodriguez, Erica; Sakurai, Katsuyasu; Xu, Jennie; Chen, Yong; Toda, Koji; Zhao, Shengli; Han, Bao-Xia; ... (11 authors) (Nature neuroscience, 2017-12)
      Humans often rank craniofacial pain as more severe than body pain. Evidence suggests that a stimulus of the same intensity induces stronger pain in the face than in the body. However, the underlying neural circuitry for ...
    • Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina. 

      Wang, Tian; Pahlberg, Johan; Cafaro, Jon; Frederiksen, Rikard; Cooper, AJ; Sampath, Alapakkam P; Field, Greg D; ... (8 authors) (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019-08)
      A major cause of human blindness is the death of rod photoreceptors. As rods degenerate, synaptic structures between rod and rod bipolar cells disappear and the rod bipolar cells extend their dendrites and occasionally make ...
    • Astrocytes refine cortical connectivity at dendritic spines. 

      Risher, WC; Patel, S; Kim, IH; Uezu, A; Bhagat, S; Wilton, DK; Pilaz, L; ... (14 authors) (Elife, 2014-12-17)
      During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this ...
    • Astrocytes: Orchestrating synaptic plasticity? 

      De Pittà, M; Brunel, N; Volterra, A (Neuroscience, 2016-05)
      Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, ...
    • Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location. 

      Graupner, Michael; Brunel, Nicolas (Proceedings of the National Academy of Sciences of the United States of America, 2012-03)
      Multiple stimulation protocols have been found to be effective in changing synaptic efficacy by inducing long-term potentiation or depression. In many of those protocols, increases in postsynaptic calcium concentration have ...
    • Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. 

      Wang, Ya-Chao; Galeffi, Francesca; Wang, Wei; Li, Xuan; Lu, Liping; Sheng, Huaxin; Hoffmann, Ulrike; ... (9 authors) (Experimental neurology, 2020-04)
      <h4>Background and purpose</h4>Ischemic stroke significantly perturbs neuronal homeostasis leading to a cascade of pathologic events causing brain damage. In this study, we assessed acute stroke outcome after chemogenetic ...
    • Estimating network parameters from combined dynamics of firing rate and irregularity of single neurons. 

      Hamaguchi, Kosuke; Riehle, Alexa; Brunel, Nicolas (Journal of neurophysiology, 2011-01)
      High firing irregularity is a hallmark of cortical neurons in vivo, and modeling studies suggest a balance of excitation and inhibition is necessary to explain this high irregularity. Such a balance must be generated, at ...
    • Frontal eye field neurons orthodromically activated from the superior colliculus. 

      Sommer, MA; Wurtz, RH (J Neurophysiol, 1998-12)
      Frontal eye field neurons orthodromically activated from the superior colliculus. J. Neurophysiol. 80: 3331-3333, 1998. Anatomical studies have shown that the frontal eye field (FEF) and superior colliculus (SC) of monkeys ...
    • Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. 

      McKinstry, Spencer U; Karadeniz, Yonca B; Worthington, Atesh K; Hayrapetyan, Volodya Y; Ozlu, M Ilcim; Serafin-Molina, Karol; Risher, W Christopher; ... (12 authors) (J Neurosci, 2014-07-09)
      Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-Q) stretch in the huntingtin (Htt) protein. Gain-of-function effects of mutant Htt have been extensively investigated ...
    • Intracellular Neural Recording with Pure Carbon Nanotube Probes. 

      Yoon, Inho; Hamaguchi, Kosuke; Borzenets, Ivan V; Finkelstein, Gleb; Mooney, Richard; Donald, Bruce R (PloS one, 2013-01)
      The computational complexity of the brain depends in part on a neuron's capacity to integrate electrochemical information from vast numbers of synaptic inputs. The measurements of synaptic activity that are crucial ...
    • Memory capacity of networks with stochastic binary synapses. 

      Dubreuil, Alexis M; Amit, Yali; Brunel, Nicolas (PLoS Comput Biol, 2014-08)
      In standard attractor neural network models, specific patterns of activity are stored in the synaptic matrix, so that they become fixed point attractors of the network dynamics. The storage capacity of such networks has ...
    • Memory maintenance in synapses with calcium-based plasticity in the presence of background activity. 

      Higgins, David; Graupner, Michael; Brunel, Nicolas (PLoS Comput Biol, 2014-10)
      Most models of learning and memory assume that memories are maintained in neuronal circuits by persistent synaptic modifications induced by specific patterns of pre- and postsynaptic activity. For this scenario to be viable, ...
    • Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning. 

      Sidlauskaite, Eva; Gibson, Jack W; Megson, Ian L; Whitfield, Philip D; Tovmasyan, Artak; Batinic-Haberle, Ines; Murphy, Michael P; ... (9 authors) (Redox biology, 2018-06)
      Developmental synapse pruning refines burgeoning connectomes. The basic mechanisms of mitochondrial reactive oxygen species (ROS) production suggest they select inactive synapses for pruning: whether they do so is unknown. ...
    • Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. 

      De Pittà, Maurizio; Brunel, Nicolas (Neural plasticity, 2016-01)
      Glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic ...
    • Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina. 

      Grove, James CR; Hirano, Arlene A; de Los Santos, Janira; McHugh, Cyrus F; Purohit, Shashvat; Field, Greg D; Brecha, Nicholas C; ... (8 authors) (PLoS biology, 2019-04)
      The stream of visual information sent from photoreceptors to second-order bipolar cells is intercepted by laterally interacting horizontal cells that generate feedback to optimize and improve the efficiency of signal ...
    • Optimal properties of analog perceptrons with excitatory weights. 

      Clopath, Claudia; Brunel, Nicolas (PLoS Comput Biol, 2013)
      The cerebellum is a brain structure which has been traditionally devoted to supervised learning. According to this theory, plasticity at the Parallel Fiber (PF) to Purkinje Cell (PC) synapses is guided by the Climbing fibers ...
    • Regulation of spine structural plasticity by Arc/Arg3.1. 

      Newpher, Thomas M; Harris, Scott; Pringle, Jasmine; Hamilton, Colleen; Soderling, Scott (Seminars in cell & developmental biology, 2018-05)
      Dendritic spines are actin-rich, postsynaptic protrusions that contact presynaptic terminals to form excitatory chemical synapses. These synaptic contacts are widely believed to be the sites of memory formation and information ...
    • Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. 

      Li, Boxing; Tadross, Michael R; Tsien, Richard W (Science, 2016-02-19)
      Voltage-gated CaV1.2 channels (L-type calcium channel α1C subunits) are critical mediators of transcription-dependent neural plasticity. Whether these channels signal via the influx of calcium ion (Ca(2+)), voltage-dependent ...
    • "Silent" NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit. 

      Sethuramanujam, Santhosh; Yao, Xiaoyang; deRosenroll, Geoff; Briggman, Kevin L; Field, Greg D; Awatramani, Gautam B (Neuron, 2017-12)
      Retinal direction-selective ganglion cells (DSGCs) have the remarkable ability to encode motion over a wide range of contrasts, relying on well-coordinated excitation and inhibition (E/I). E/I is orchestrated by a diverse ...