Now showing items 1-15 of 15

    • Acetylcholine Modulates Cerebellar Granule Cell Spiking by Regulating the Balance of Synaptic Excitation and Inhibition. 

      Fore, Taylor R; Taylor, Benjamin N; Brunel, Nicolas; Hull, Court (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020-04)
      Sensorimotor integration in the cerebellum is essential for refining motor output, and the first stage of this processing occurs in the granule cell layer. Recent evidence suggests that granule cell layer synaptic integration ...
    • Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina. 

      Wang, Tian; Pahlberg, Johan; Cafaro, Jon; Frederiksen, Rikard; Cooper, AJ; Sampath, Alapakkam P; Field, Greg D; ... (8 authors) (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019-08)
      A major cause of human blindness is the death of rod photoreceptors. As rods degenerate, synaptic structures between rod and rod bipolar cells disappear and the rod bipolar cells extend their dendrites and occasionally make ...
    • Astrocytes: Orchestrating synaptic plasticity? 

      De Pittà, M; Brunel, N; Volterra, A (Neuroscience, 2016-05)
      Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, ...
    • Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location. 

      Graupner, Michael; Brunel, Nicolas (Proceedings of the National Academy of Sciences of the United States of America, 2012-03)
      Multiple stimulation protocols have been found to be effective in changing synaptic efficacy by inducing long-term potentiation or depression. In many of those protocols, increases in postsynaptic calcium concentration have ...
    • Coherence potentials: loss-less, all-or-none network events in the cortex. 

      Thiagarajan, Tara C; Lebedev, Mikhail A; Nicolelis, Miguel A; Plenz, Dietmar (PLoS Biol, 2010-01-12)
      Transient associations among neurons are thought to underlie memory and behavior. However, little is known about how such associations occur or how they can be identified. Here we recorded ongoing local field potential (LFP) ...
    • Computational inference of neural information flow networks. 

      Smith, V Anne; Yu, Jing; Smulders, Tom V; Hartemink, Alexander J; Jarvis, Erich D (PLoS Comput Biol, 2006-11-24)
      Determining how information flows along anatomical brain pathways is a fundamental requirement for understanding how animals perceive their environments, learn, and behave. Attempts to reveal such neural information flow ...
    • Corollary discharge across the animal kingdom. 

      Crapse, Trinity B; Sommer, Marc A (Nat Rev Neurosci, 2008-08)
      Our movements can hinder our ability to sense the world. Movements can induce sensory input (for example, when you hit something) that is indistinguishable from the input that is caused by external agents (for example, when ...
    • Correlated firing among major ganglion cell types in primate retina. 

      Greschner, Martin; Shlens, Jonathon; Bakolitsa, Constantina; Field, Greg D; Gauthier, Jeffrey L; Jepson, Lauren H; Sher, Alexander; ... (9 authors) (The Journal of physiology, 2011-01)
      Retinal ganglion cells exhibit substantial correlated firing: a tendency to fire nearly synchronously at rates different from those expected by chance. These correlations suggest that network interactions significantly shape ...
    • Differential expression of glutamate receptors in avian neural pathways for learned vocalization. 

      Wada, Kazuhiro; Sakaguchi, Hironobu; Jarvis, Erich D; Hagiwara, Masatoshi (J Comp Neurol, 2004-08-09)
      Learned vocalization, the substrate for human language, is a rare trait. It is found in three distantly related groups of birds-parrots, hummingbirds, and songbirds. These three groups contain cerebral vocal nuclei for learned ...
    • For whom the bird sings: context-dependent gene expression. 

      Jarvis, ED; Scharff, C; Grossman, MR; Ramos, JA; Nottebohm, F (Neuron, 1998-10)
      Male zebra finches display two song behaviors: directed and undirected singing. The two differ little in the vocalizations produced but greatly in how song is delivered. "Directed" song is usually accompanied by a courtship ...
    • Frontal eye field sends delay activity related to movement, memory, and vision to the superior colliculus. 

      Sommer, MA; Wurtz, RH (J Neurophysiol, 2001-04)
      Many neurons within prefrontal cortex exhibit a tonic discharge between visual stimulation and motor response. This delay activity may contribute to movement, memory, and vision. We studied delay activity sent from the frontal ...
    • Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. 

      De Pittà, Maurizio; Brunel, Nicolas (Neural plasticity, 2016-01)
      Glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic ...
    • Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina. 

      Grove, James CR; Hirano, Arlene A; de Los Santos, Janira; McHugh, Cyrus F; Purohit, Shashvat; Field, Greg D; Brecha, Nicholas C; ... (8 authors) (PLoS biology, 2019-04)
      The stream of visual information sent from photoreceptors to second-order bipolar cells is intercepted by laterally interacting horizontal cells that generate feedback to optimize and improve the efficiency of signal ...
    • Spike avalanches exhibit universal dynamics across the sleep-wake cycle. 

      Ribeiro, Tiago L; Copelli, Mauro; Caixeta, Fábio; Belchior, Hindiael; Chialvo, Dante R; Nicolelis, Miguel AL; Ribeiro, Sidarta (PLoS One, 2010-11-30)
      BACKGROUND: Scale-invariant neuronal avalanches have been observed in cell cultures and slices as well as anesthetized and awake brains, suggesting that the brain operates near criticality, i.e. within a narrow margin between ...
    • Toward a Neurocentric View of Learning. 

      Titley, Heather K; Brunel, Nicolas; Hansel, Christian (Neuron, 2017-07)
      Synaptic plasticity (e.g., long-term potentiation [LTP]) is considered the cellular correlate of learning. Recent optogenetic studies on memory engram formation assign a critical role in learning to suprathreshold activation ...