Browsing by Subject "Systematic biology"
Now showing items 1-20 of 21
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A Framework for Dissecting and Applying Bacterial Antibiotic Responses
(2017)An essential property of microbial communities is the ability to survive a disturbance. This is readily observed in bacteria, which have developed the ability to survive every antibiotic treatment at an alarming rate, considering ... -
A Next-Generation Approach to Systematics in the Classic Reticulate <italic>Polypodium vulgare<italic> Species Complex (Polypodiaceae)
(2014)The <italic>Polypodium vulgare<italic> complex (Polypodiaceae) comprises a well-studied group of fern taxa whose members are cryptically differentiated morphologically and have generated a confusing and highly reticulate ... -
A Systems-Level Analysis of an Epithelial to Mesenchymal Transition
(2012)Embryonic development occurs with precisely timed morphogenetic cell movements directed by complex gene regulation. In this orchestrated series of events, some epithelial cells undergo extensive changes to become free moving ... -
Development and Application of a quantitative Mass spectrometry based Platform for Thermodynamic Analysis of Protein interaction Networks
(2013)The identification and quantification of protein-protein interactions in large scale is critical to understanding biological processes at a systems level. Current approaches for the analysis of protein -protein interactions ... -
Evolution of Edaphic Ecology in Ceanothus (Rhamnaceae)
(2011)Edaphic factors--those pertaining to the substrate or soil--are thought to play an important role in the diversification of flowering plants. Although edaphic factors are widely interpreted as causal agents in plant ... -
Evolution of mating systems in Sphagnum peatmosses
(2013)Bryophytes, by their haploid dominant life cycle, possess several unique qualities ideal for study of mating patterns. In particular, the possibility of intragametophytic selfing in some species, and the vegetative propagation ... -
Evolutionary Patterns and Processes in the Desert-Adapted Fern Genus Myriopteris (Pteridaceae)
(2014)This dissertation investigates the processes of hybridation, polyploidy, and apomixis and their roles in the evolution of myriopterid ferns. First, I examine patterns of hybridization in members of the Cheilanthes yavapensis ... -
Genomic Insights Into the Lichen Symbiosis: <italic>Cladonia grayi</italic> as a Model Lichen
(2011)Lichens are symbioses between a fungus and a photosynthesizing partner such as a green alga or a cyanobacterium. Unlike mycorrhizal or rhizobial symbioses, the lichen symbiosis is not well understood either morphologically ... -
Information Encoding and Decoding in Bacteria
(2019)Bacteria are found throughout the environment, from the air to the soil, but more importantly, they reside within the human body. Crucial to their survival in each of these environments is the constant interplay between ... -
Information Encoding and Decoding in Bacteria
(2019)Bacteria are found throughout the environment, from the air to the soil, but more importantly, they reside within the human body. Crucial to their survival in each of these environments is the constant interplay between ... -
Integrative Analysis of the Myc and E2F pathway Reveal the Roles for microRNAs in Cell Fate Control
(2011)Cancer is a disease state that arises as a result of multiple alterations in signaling pathways that are critical for making key cell fate decisions in normal cells. Understanding how these pathways operate under normal ... -
Mistakes and Small Steps Can Take You Far: Exploring Fern Variation and Biogeography in Cheilanthes (Pteridaceae), with a Focus on Spore Diversity and Range Expansion in Cheilanthes distans
(2022)Why do species exist where they do? Understanding the forces and processes that shape species’ ranges—and that affect their dispersal and range expansion—have long fascinated biologists. In this work, I focus on understanding ... -
Phylogenetics of Cystopteridaceae: Reticulation and Divergence in a Cosmopolitan Fern Family
(2012)The fern family Cystopteridaceae has been a thorn in the side of fern phylogeneticists, on many levels. Until this thesis, its basic existence (as a deeply isolated clade) and composition were unrecognized, hypotheses as ... -
PLEUROCARPOUS MOSSES IN SPACE AND TIME: BIOGEOGRAPHY AND EVOLUTION OF THE HOOKERIALES
(2012)Morphological characters from the gametophyte and sporophyte generations have been used in land plants to infer relationships and construct classifications, but sporophytes provide the vast majority of data for the systematics ... -
Quantifying and Inhibiting Horizontal Gene Transfer-Mediated Antibiotic Resistance
(2017)Antibiotic discovery and widespread usage has revolutionized the treatment of infectious diseases. However, this golden age of modern-day medicine is threatened by the increasing prevalence of antibiotic-resistant pathogens. ... -
Reinterpreting the organizing principles of sex determination and gonadogenesis in the mouse
(2021)The mouse gonad begins its development as a bipotential primordia, capable of developing into a testis or ovary depending on the presence of the sex-determining gene, Sry. In the XY gonad, opposing pro-testis and pro-ovary ... -
Sequence and Structural Determinants of Specificity Differences between Paralogous Transcription Factors
(2016)Transcription factors (TFs) control the temporal and spatial expression of target genes by interacting with DNA in a sequence-specific manner. Recent advances in high throughput experiments that measure TF-DNA interactions ... -
Systematics and Ecology of Truffles (Tuber)
(2009)The truffle genus Tuber (Ascomycota, Pezizales, Tuberaceae) produces underground mushrooms widely sought as edible fungi. Tuber species are distributed throughout Northern hemisphere forests and form obligate ectomycorrhizal ... -
Systematics, Phylogeography and Ecology of Elaphomycetaceae
(2011)This dissertation is an investigation of the systematics, phylogeography, and ecology of a globally distributed fungal family, the Elaphomycetaceae. In Chapter 1, we assess the literature on fungal phylogeography, reviewing ... -
The Principles and Applications of Plasmid Transfer in Microbial Communities
(2022)Conjugative plasmids can mediate the spread and maintenance of diverse traits and functions in microbial communities. This role depends on the plasmid’s ability to persist in a population. However, for a community consisting ...
