Browsing by Subject "T cells"
Now showing items 1-9 of 9
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Analysis of TCR Signaling and Erk Activation in T Cell Development and Autoimmunity
(2012)<p>LAT is a transmembrane adaptor protein that is critical for the emanation of signals downstream of the TCR. Following TCR engagement, LAT is phosphorylated on multiple tyrosine residues, allowing it to serve as a scaffold ... -
Harnessing T Cell Generation and Metabolism to Modulate T Cell Recovery Following Radiation Exposure and Bone Marrow Transplantation
(2022)Total body irradiation (TBI) causes profound suppression of hematopoiesis and T cell depletion, increasing chances of morbidity associated with opportunistic infections in the lymphopenic condition. Currently, therapeutic ... -
Metabolism Regulates the Fate and Function of T Lymphocytes
(2016)Proper balancing of the activities of metabolic pathways to meet the challenge of providing necessary products for biosynthetic and energy demands of the cell is a key requirement for maintaining cell viability and allowing ... -
Nutritional effects on T-cell immunometabolism.
(Eur J Immunol, 2017-01-05)T cells are highly influenced by nutrient uptake from their environment, and changes in overall nutritional status, such as malnutrition or obesity, can result in altered T-cell metabolism and behavior. In states of severe ... -
Regulation of Adaptive Immune Cells by Sirtuins
(Frontiers in Endocrinology, 2019-07-11) -
RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics.
(Molecular cancer, 2022-02-21)Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. The cellular and molecular nature of the TIME influences cancer progression ... -
Role of T cells in malnutrition and obesity.
(Front Immunol, 2014)Nutritional status is critically important for immune cell function. While obesity is characterized by inflammation that promotes metabolic syndrome including cardiovascular disease and insulin resistance, malnutrition can ... -
The Regulation of Type 3 ILC and γδ T Cell Plasticity
(2022)Lymphocytes take on effector programs coordinated by lineage-defining transcription factors (LDTF), resulting in the production of cytokines that fight specific types of pathogens. Therefore, both adaptive and innate lymphocyte ... -
Videos of Sipuleucel-T Programmed T Cells Lysing Cells That Express Prostate Cancer Target Antigens.
(Journal of the National Cancer Institute, 2021-02-25)Sipuleucel-T, an autologous cellular immunotherapy, was approved to treat metastatic castration-resistant prostate cancer in 2010 in the United States. Treatment with sipuleucel-T primes the immune system to target prostate ...
