Now showing items 1-5 of 5

    • Analysis of TCR Signaling and Erk Activation in T Cell Development and Autoimmunity 

      Fuller, Deirdre Marie (2012)
      <p>LAT is a transmembrane adaptor protein that is critical for the emanation of signals downstream of the TCR. Following TCR engagement, LAT is phosphorylated on multiple tyrosine residues, allowing it to serve as a scaffold ...
    • Metabolism Regulates the Fate and Function of T Lymphocytes 

      Kishton, Rigel Joseph (2016)
      Proper balancing of the activities of metabolic pathways to meet the challenge of providing necessary products for biosynthetic and energy demands of the cell is a key requirement for maintaining cell viability and allowing ...
    • Nutritional effects on T-cell immunometabolism. 

      Cohen, Sivan; Danzaki, K; MacIver, Nancie Jo (Eur J Immunol, 2017-01-05)
      T cells are highly influenced by nutrient uptake from their environment, and changes in overall nutritional status, such as malnutrition or obesity, can result in altered T-cell metabolism and behavior. In states of severe ...
    • Regulation of Adaptive Immune Cells by Sirtuins 

      MacIver, Nancie; Warren, Jonathan L; MacIver, Nancie J (Frontiers in Endocrinology, 2019-07-11)
    • Role of T cells in malnutrition and obesity. 

      Gerriets, VA; MacIver, Nancie Jo (Front Immunol, 2014)
      Nutritional status is critically important for immune cell function. While obesity is characterized by inflammation that promotes metabolic syndrome including cardiovascular disease and insulin resistance, malnutrition can ...