Browsing by Subject "TGF-beta"
Now showing items 1-3 of 3
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Ectodomain Shedding of TGF-beta Receptors: Role in Signaling and Breast Cancer Biology
(2013)The transforming growth factor beta (TGF-beta) signaling pathway is a critical regulator of multiple biological processes that are involved in cancer progression, such as proliferation, migration, invasion and metastasis. ... -
Inhibition of TGFβ Signaling Does Not Improve the Limited Proliferative Response to Nkx6.1 Or Pdx-1 Overexpression in Aged Rat Islets
(2015)A deficiency in functional pancreatic beta-cells is a defining feature in type 1 and type 2 diabetes. The development of therapeutic strategies for replacement and regeneration of beta-cell mass is a key objective of current ... -
Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
(2019)The type III TGF-β receptor (TβRIII) is a TGF-β co-receptor that presents ligand to the type II TGF-β receptor to initiate signaling. TβRIII also undergoes ectodomain shedding to release a soluble form (sTβRIII) that can ...
