Browsing by Subject "TRPV Cation Channels"
Now showing items 1-7 of 7
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Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux.
(Cell Rep, 2015-12-15)Calcium signaling has long been associated with key events of immunity, including chemotaxis, phagocytosis, and activation. However, imaging and manipulation of calcium flux in motile immune cells in live animals remain ... -
Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.
(Pain, 2013-08)Temporomandibular joint disorder (TMJD) is known for its mastication-associated pain. TMJD is medically relevant because of its prevalence, severity, chronicity, the therapy-refractoriness of its pain, and its largely elusive ... -
Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
(J Biol Chem, 2016-05-06)TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory neurons; however, the contribution of the channel in either cell to neurosensory function remains to be elucidated. We recently reported TRPV4 ... -
TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.
(Nat Commun, 2014-09-02)Animals need to sense and react to potentially dangerous environments. TRP ion channels participate in nociception, presumably via Ca(2+) influx, in most animal species. However, the relationship between ion permeation and ... -
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.
(Pain, 2014-12)Detection of external irritants by head nociceptor neurons has deep evolutionary roots. Irritant-induced aversive behavior is a popular pain model in laboratory animals. It is used widely in the formalin model, where formaldehyde ... -
TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.
(Environ Health Perspect, 2011-06)BACKGROUND: Human respiratory epithelia function in airway mucociliary clearance and barrier function and have recently been implicated in sensory functions. OBJECTIVE: We investigated a link between chronic obstructive ... -
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.
(Proc Natl Acad Sci U S A, 2013-08-20)At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin ...
