Browsing by Subject "Therapeutic Resistance"
Now showing items 1-3 of 3
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Overcoming Therapeutic Resistance by Targeting Oncogene-Driven and Targeted-Therapy Induced Cancer Dependencies
(2020)Targeted therapies rarely yield complete tumor responses, and the residual cancer cells that survive upfront treatment act as a reservoir from which eventual resistant disease emerges. Here, we explore several clinically ... -
Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells
(2010)Apoptotic dysregulation is a hallmark of cancer cells. The inability of cancer cells to undergo apoptosis may lead to therapeutic resistance. Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer ... -
Stromal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in Glioblastoma
(2022)Glioblastoma (GBM) is notorious for its immunosuppressive tumor microenvironment (TME). GBM is universally lethal and remains highly refractory to immunotherapy, including immune checkpoint blockade (ICB). Resistance to ...
