Browsing by Subject "Toxicology"
Now showing items 1-20 of 39
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Characterizing and predicting the interaction of proteins with nanoparticles
(2023)Nanoparticles are being used or implemented in a wide array of applications including health care, cosmetics, automotive, food, beverage, coatings, consumer electronics, and coatings. Despite this widespread use, we are ... -
Characterizing Environmental Per- and Polyfluoroalkyl Substance (PFAS) Exposure and Effects in North Carolina Communities
(2022)Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals used in a wide array of products and applications (e.g., nonstick cookware, waterproof and water-repellent textiles, firefighting foam). Following their ... -
Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust
(2015)Accumulating evidence is suggesting that exposure to some environmental contaminants may alter adipogenesis, resulting in accumulation of adipocytes, and often significant weight gain. Thus these types of contaminants are ... -
Contaminant Interactions and Biological Effects of Single-walled Carbon Nanotubes in a Benthic Estuarine System
(2013)Single-walled carbon nanotubes (SWNT) are highly ordered filamentous nanocarbon structures. As their commercial and industrial use becomes more widespread, it is anticipated that SWNT will enter the environment through waste ... -
Developmental Neurotoxicity of Silver and Silver Nanoparticles Modeled In Vitro and In Vivo
(2010)Background: Silver nanoparticles (AgNPs) act as antimicrobials by releasing monovalent silver (Ag+) and are increasingly used in consumer products, thus elevating exposures in human and environmental populations. Materials ... -
Effects of chemical exposures on mitochondrial mutagenesis across species
(2022)Mitochondria are essential organelles required for all eukaryotic life on earth. Each organelle contains multiple copies of the mitochondrial genome (mtDNA) that encodes genes essential for energy production. Mutations in ... -
Effects of Toxic Metal Exposures and Their Mixtures on Adverse Health Outcomes in the Peruvian Amazon
(2022)Non-essential trace metals (lead, mercury, arsenic, and cadmium) are ubiquitous in our environment and have overlapping routes of exposure, yet mixed trace metal exposures are rarely considered in epidemiological studies. ... -
Endocrine and Neurobehavioral Effects from Flame Retardant Exposure in Early and Juvenile Life Stages of Zebrafish
(2015)Polybrominated diphenyl ethers (PBDEs) are a class of flame retardant chemicals that were added to furniture foam, electronics, plastics, and some textiles to reduce their flammability. While PBDEs have been phased out ... -
Engineering a Biofilm for the Biodegradation of Polycyclic Aromatic Hydrocarbons in Estuarine Sediment
(2019)Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants that accumulate in soils and sediment due to their physicochemical properties. In these environmental matrices, PAHs are predominantly transformed ... -
Environmental toxicant effects on the dopaminergic system in the nematode Caenorhabditis elegans: Strengths and limitations of various approaches to analysis
(2019)In order to develop a better understanding of the role environmental toxicants may play in the onset and progression of neurodegenerative diseases, it has become increasingly important to optimize sensitive methods for quickly ... -
Exposure, Metabolism, and in Vitro Effects of Isopropylated and Tert-butylated Triarylphosphate Ester (ITP & TBPP) Flame Retardants and Plasticizers
(2019)Following the phase-out of polybrominated diphenyl ethers (PBDEs) in the early 2000s, organophosphate esters (OPEs) emerged as PBDE substitutes and have been applied to furniture foam, electronics, building materials, and ... -
Genetic Sensitivity to Mitochondrial Toxicity
(2017)Mitochondria are the main cellular producers of ATP, and play key roles in cellular signaling and apoptosis. Mitochondria also contain their own genomes (mtDNA), which encode 13 subunits of the electron transport chain (ETC), ... -
Genomic Signatures of Disease and Environmental Exposure in the Peripheral Blood
(2011)My thesis research has centered on the concept of the peripheral blood cell (PBC) as an indicator of disease and environmental exposure. The PBC is not only easily accessible and constantly replenished, but it provides a ... -
Halogenated Organophosphate Flame Retardants: Developmental Toxicity and Endocrine Disruptive Effects
(2015)Following the phase out of polybrominated diphenyl ethers (PBDEs), manufacturers turned to several alternative flame retardants (FRs) to meet flammability standards. Organophosphate FRs (OPFRs), and in particular ... -
Impacts of Mountaintop Removal Coal Mining on the Mud River, West Virginia: Selenium Accumulation, Trophic Transfer, and Toxicity in Fish
(2014)Selenium (Se) is a micronutrient necessary for the function of a variety of important enzymes; Se also exhibits a narrow range in concentrations between essentiality and toxicity. Oviparous vertebrates such as birds and ... -
Incorporating Environmental Realism into the Toxicity of Nanoparticles to Early Life Stage Fish
(2015)As the production and use of nanoparticles (NPs) has increased, so has concern over their effects on the environment and aquatic organisms. While the majority of research on the toxicity of NPs has been performed using controlled ... -
Integrated Bayesian Network Models to Predict the Fate and Transport of Natural Estrogens at a Swine Farrowing CAFO
(2012)Natural steroidal estrogen hormones in swine wastes generated from Concentrated Animal Feeding Operations (CAFOs) have become a potential pollutant to many aquatic environments due to their adverse impacts on the reproductive ... -
Investigations into the genotoxic and immunological outcomes following mercury exposure in Peruvian communities and Caenorhabditis elegans
(2017)Mercury is a pollutant of global concern and is considered a priority compound to many organizations, including the Agency for Toxic Substances and Disease Registry (ATSDR), the US Environmental Protection Agency (USEPA), ... -
Later Life Consequences of Developmental Mitochondrial DNA Damage in C. elegans
(2015)Mitochondria are responsible for producing the vast majority of cellular ATP, and are therefore critical to organismal health [1]. They contain thir own genomes (mtDNA) which encode 13 proteins that are all subunits of the ... -
Later Life Consequences of Subteratogenic Exposure to a Complex PAH Mixture in the Atlantic Killifish (Fundulus heteroclitus)
(2015)Subteratogenic and other low-level chronic exposures to toxicant mixtures are an understudied threat to environmental and human health. It is especially important to understand the effects of these exposures for contaminants, ...
