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Browsing by Subject "Tuberculosis"
Now showing items 1-20 of 30
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A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis.
(Nature communications, 2022-08)Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis (Mtb) and is a major cause of morbidity and mortality. Successful treatment requires strict adherence to drug regimens for prolonged periods ... -
A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP).
(BMC Med, 2016-03-23)BACKGROUND: The standard 6-month four-drug regimen for the treatment of drug-sensitive tuberculosis has remained unchanged for decades and is inadequate to control the epidemic. Shorter, simpler regimens are urgently needed ... -
A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania.
(BMC Infect Dis, 2014-02-20)BACKGROUND: Routine tuberculosis culture remains unavailable in many high-burden areas, including Tanzania. This study sought to determine the impact of providing mycobacterial culture results over standard of care ... -
Access to and affordability of healthcare for TB patients in China: issues and challenges.
(Infect Dis Poverty, 2016-01-29)This paper introduces the background, aim and objectives of the project entitled "China-the Gates Foundation Collaboration on TB Control in China" that has been underway for many years. It also summarizes the key findings ... -
An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection.
(PLoS One, 2013)While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, ... -
Are tuberculosis patients adherent to prescribed treatments in China? Results of a prospective cohort study.
(Infect Dis Poverty, 2016-05-05)BACKGROUND: Tuberculosis (TB) patients face numerous difficulties adhering to the long-term, rigorous TB treatment regimen. Findings on TB patients' treatment adherence vary across existing literature and official reports. ... -
Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study.
(Clin Infect Dis, 2012-07)BACKGROUND: Disseminated tuberculosis is a major health problem in countries where generalized human immunodeficiency virus (HIV) infection epidemics coincide with high tuberculosis incidence rates; data are limited on patient ... -
CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections.
(Dis Model Mech, 2015-12)Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae have been used to directly observe infection in vivo; however, such larvae ... -
Early versus delayed fixed dose combination abacavir/lamivudine/zidovudine in patients with HIV and tuberculosis in Tanzania.
(AIDS Res Hum Retroviruses, 2009-12)Fixed dose combination abacavir/lamivudine/zidovudine (ABC/3TC/ZDV) among HIV-1 and tuberculosis (TB)-coinfected patients was evaluated and outcomes between early vs. delayed initiation were compared. In a randomized, pilot ... -
Examining Mycobacterial Interactions with Host Cellular Pathways
(2015)Tuberculosis is a devastating disease that has been plaguing humankind for millennia. Co-evolution of humans with Mycobacterium tuberculosis, the causative agent of the disease, has allowed for the pathogen to possess an ... -
Extrapulmonary tuberculosis, human immunodeficiency virus, and foreign birth in North Carolina, 1993 - 2006.
(BMC Public Health, 2008-04-04)BACKGROUND: The proportion of extrapulmonary tuberculosis (EPTB) reported in the United States has been gradually increasing. HIV infection and foreign birth are increasingly associated with tuberculosis and understanding ... -
Factor Associated with Treatment Initiation of Multidrug Resistance Tuberculosis in Jakarta, Indonesia: A Mixed-Method Study
(2021)Background: Indonesia has one of the highest TB burdens in the world and is one of ten countries that accounted for 77% of the global gap between treatment enrollment and the estimated number of new cases of MDR/RR-TB in ... -
Factors Associated with Tuberculosis Treatment Default Amongst Migrant and Mobile Populations in Myanmar
(2017)Background: Ending the global tuberculosis (TB) epidemic by 2035 will substantially depend on the effective control of the “lost to follow-up” (LTFU) from TB treatment. Myanmar is one of the 14 countries with high burden ... -
Factors Influencing Hospitalization Rates and Inpatient Cost of Patients with Tuberculosis in Jiangsu Province, China: An Uncontrolled before and after Study.
(International journal of environmental research and public health, 2019-08)OBJECTIVE:The China Center for Disease Control and Prevention (CDC) introduced an innovative financing model of tuberculosis (TB) care and control with the aim of standardizing TB treatment and reducing the financial burden ... -
Feasibility and willingness-to-pay for integrated community-based tuberculosis testing.
(BMC Infect Dis, 2011-11-02)BACKGROUND: Community-based screening for TB, combined with HIV and syphilis testing, faces a number of barriers. One significant barrier is the value that target communities place on such screening. METHODS: Integrated ... -
Genomic, Genetic, and Functional Interrogation of Mycobacterium tuberculosis Outbreak Strains
(2017)In the past 200 years, tuberculosis (TB) has caused more deaths than any other infectious disease and currently infects more people than it has at any other time in human history. Mycobacterium tuberculosis (Mtb), the etiological ... -
Geographic information system-based screening for TB, HIV, and syphilis (GIS-THIS): a cross-sectional study.
(PLoS One, 2012)OBJECTIVE: To determine the feasibility and case detection rate of a geographic information systems (GIS)-based integrated community screening strategy for tuberculosis, syphilis, and human immunodeficiency virus (HIV). ... -
Histoplasmosis among hospitalized febrile patients in northern Tanzania.
(Trans R Soc Trop Med Hyg, 2012-08)Histoplasmosis may be common in East Africa but the diagnosis is rarely confirmed. We report 9 (0.9%) cases of probable histoplasmosis retrospectively identified among 970 febrile inpatients studied in northern Tanzania. ... -
How Testing Serves African Americans in Epidemics, Past and Present: Applying Lessons from Tuberculosis to COVID-19 in the United States
(2021-02-12)Rather than lacking the resources, knowledge or empirical evidence to successfully address testing inequities in the African American community, the U.S. lacks the imagination and commitment to directly confronting structural ... -
Impact of Community-Based DOT on Tuberculosis Treatment Outcomes: A Systematic Review and Meta-Analysis.
(PLoS One, 2016)BACKGROUND: Poor adherence to tuberculosis (TB) treatment can lead to prolonged infectivity and poor treatment outcomes. Directly observed treatment (DOT) seeks to improve adherence to TB treatment by observing patients ...
