Now showing items 1-10 of 10

    • Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer. 

      Wang, Zhongqiu; Sturgis, Erich M; Guo, Wei; Song, Xicheng; Zhang, Fenghua; Xu, Li; Wei, Qingyi; ... (8 authors) (PloS one, 2012-01)
      p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis, through which inflammation/immune responses control ...
    • CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. 

      Ke, Hengning; Augustine, Christina K; Gandham, Vineela D; Jin, Jane Y; Tyler, Douglas S; Akiyama, Steven K; Hall, Russell P; ... (8 authors) (J Invest Dermatol, 2013-01)
      The molecular mechanisms mediating cylindromatosis (CYLD) tumor suppressor function appear to be manifold. Here, we demonstrate that, in contrast to the increased levels of phosphorylated c-Jun NH(2)-terminal kinase (pJNK), ...
    • DOK2 inhibits EGFR-mutated lung adenocarcinoma. 

      Berger, Alice H; Chen, Ming; Morotti, Alessandro; Janas, Justyna A; Niki, Masaru; Bronson, Roderick T; Taylor, Barry S; ... (12 authors) (PloS one, 2013-01)
      Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and cancer ...
    • Endosome and INPP4B. 

      Chew, Chen Li; Chen, Ming; Pandolfi, Pier Paolo (Oncotarget, 2016-01)
    • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 

      Doan, Phuong L; Himburg, Heather A; Helms, Katherine; Russell, J Lauren; Fixsen, Emma; Quarmyne, Mamle; Harris, Jeffrey R; ... (12 authors) (Nat Med, 2013-03)
      The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow serum of ...
    • Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. 

      Lee, Ying-Ying; Mok, Myth Ts; Kang, Wei; Yang, Weiqin; Tang, Wenshu; Wu, Feng; Xu, Liangliang; ... (20 authors) (Nucleic acids research, 2018-09)
      Genomic sequencing of hepatocellular carcinoma (HCC) uncovers a paucity of actionable mutations, underscoring the necessity to exploit epigenetic vulnerabilities for therapeutics. In HCC, EZH2-mediated H3K27me3 represents ...
    • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 

      Soubry, A; Murphy, SK; Wang, F; Huang, Z; Vidal, AC; Fuemmeler, BF; Kurtzberg, J; ... (11 authors) (International journal of obesity (2005), 2015-04)
      Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed ...
    • Pills of PTEN? In and out for tumor suppression. 

      Papa, Antonella; Chen, Ming; Pandolfi, Pier Paolo (Cell research, 2013-10)
      The tumor-suppressive activity of PTEN has always been attributed to its endogenous intracellular function. Recently two different groups have demonstrated that PTEN is secreted/exported into the extracellular environment ...
    • Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. 

      Lee, Yu-Ru; Chen, Ming; Lee, Jonathan D; Zhang, Jinfang; Lin, Shu-Yu; Fu, Tian-Min; Chen, Hao; ... (27 authors) (Science (New York, N.Y.), 2019-05)
      Activation of tumor suppressors for the treatment of human cancer has been a long sought, yet elusive, strategy. PTEN is a critical tumor suppressive phosphatase that is active in its dimer configuration at the plasma membrane. ...
    • TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. 

      Ci, Xinxin; Kuraoka, Masayuki; Wang, Hongxia; Carico, Zachary; Hopper, Kristen; Shin, Jinwook; Deng, Xuming; ... (11 authors) (PLoS One, 2015)
      Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially ...