Now showing items 1-6 of 6

    • Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer. 

      Wei, Qingyi; Wang, Zhongqiu; Sturgis, Erich M; Guo, Wei; Song, Xicheng; Zhang, Fenghua; Xu, Li; ... (8 authors) (PloS one, 2012-01)
      p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis, through which inflammation/immune responses control ...
    • CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. 

      Akiyama, SK; Augustine, CK; Gandham, VD; Hall, RP; Jin, JY; Ke, H; Tyler, Douglas S; ... (8 authors) (J Invest Dermatol, 2013-01)
      The molecular mechanisms mediating cylindromatosis (CYLD) tumor suppressor function appear to be manifold. Here, we demonstrate that, in contrast to the increased levels of phosphorylated c-Jun NH(2)-terminal kinase (pJNK), ...
    • DOK2 inhibits EGFR-mutated lung adenocarcinoma. 

      Chen, Ming; Berger, Alice H; Morotti, Alessandro; Janas, Justyna A; Niki, Masaru; Bronson, Roderick T; Taylor, Barry S; ... (12 authors) (PloS one, 2013-01)
      Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and cancer ...
    • Endosome and INPP4B. 

      Chen, Ming; Chew, Chen Li; Pandolfi, Pier Paolo (Oncotarget, 2016-01)
    • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 

      Chao, Nelson J; Chute, JP; Deoliviera, D; Doan, Phuong Linh; Fixsen, Emma; Harris, Jeffrey R; Helms, K; ... (12 authors) (Nat Med, 2013-03)
      The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow serum of ...
    • TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. 

      Carico, Z; Ci, X; Deng, X; Hopper, K; Kelsoe, Garnett; Kuraoka, M; Qiu, Y; ... (11 authors) (PLoS One, 2015)
      Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially ...