Now showing items 1-3 of 3

    • Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism. 

      Tang, Wanli; Wu, Judy Qiju; Chen, Chen; Yang, Chih-Sheng; Guo, Jessie Yanxiang; Freel, Christopher D; Kornbluth, Sally (Mol Biol Cell, 2010-08-01)
      Vertebrate eggs are arrested at Metaphase II by Emi2, the meiotic anaphase-promoting complex/cyclosome (APC/C) inhibitor. Although the importance of Emi2 during oocyte maturation has been widely recognized and its regulation ...
    • Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. 

      Casaletto, Jessica B; Nutt, Leta K; Wu, Qiju; Moore, Jonathan D; Etkin, Laurence D; Jackson, Peter K; Hunt, Tim; ... (8 authors) (J Cell Biol, 2005-04-11)
      Degradation of specific protein substrates by the anaphase-promoting complex/cyclosome (APC) is critical for mitotic exit. We have identified the protein Xenopus nuclear factor 7 (Xnf7) as a novel APC inhibitor able to regulate ...
    • Ubiquitylation of p53 by the APC/C inhibitor Trim39. 

      Zhang, Liguo; Huang, Nai-Jia; Chen, Chen; Tang, Wanli; Kornbluth, Sally (Proc Natl Acad Sci U S A, 2012-12-18)
      Tripartite motif 39 (Trim39) is a RING domain-containing E3 ubiquitin ligase able to inhibit the anaphase-promoting complex (APC/C) directly. Through analysis of Trim39 function in p53-positive and p53-negative cells, we ...