Now showing items 1-3 of 3

    • Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β. 

      Hughes, Francis M; Sexton, Stephanie J; Jin, Huixia; Govada, Vihasa; Purves, J Todd (American journal of physiology. Renal physiology, 2017-09)
      Bladder outlet obstruction (BOO) triggers inflammation in the bladder through the NLRP3 inflammasome. BOO also activates fibrosis, which is largely responsible for the decompensation of the bladder in the chronic state. ...
    • Inflammasomes in the urinary tract: a disease-based review. 

      Purves, J Todd; Hughes, F Monty (American journal of physiology. Renal physiology, 2016-10)
      Inflammasomes are supramolecular structures that sense molecular patterns from pathogenic organisms or damaged cells and trigger an innate immune response, most commonly through production of the proinflammatory cytokines ...
    • The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction. 

      Hughes, Francis M; Hill, Hayden M; Wood, Case M; Edmondson, Andrew T; Dumas, Aliya; Foo, Wen-Chi; Oelsen, James M; ... (9 authors) (The Journal of urology, 2016-05)
      While bladder outlet obstruction is well established to elicit an inflammatory reaction in the bladder that leads to overactive bladder and fibrosis, little is known about the mechanism by which this is initiated. NLRs (NOD-like ...